| Gene Symbol |
Angptl4
|
| Entrez Gene |
57875
|
| Alt Symbol |
Arp4, Bk89, Fiaf, Hfarp, Ng27, Pgar, Pgarg, Pp1158
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
angiopoietin-like 4
|
| Other Description |
425O18-1|angiopoietin-like protein 4|angiopoietin-related protein 4|fasting-induced adipose factor|fibrinogen/angiopoietin-related protein|hepatic fibrinogen/angiopoietin-related protein|major histocompatibility complex region NG27|secreted protein Bk89
|
| Swissprots |
Q9JHX7 Q9JLX7 Q78ZJ9 Q9Z1P8
|
| Accessions |
AAC97965 AAO17378 EDL10208 Q9Z1P8 AB054540 BAB83079 AF123261 AAF42969 AF169313 AAF62869 AF278699 AAF86342 AK009161 BAC25242 AK014564 BAB29431 AK032491 AK132761 BAE21342 AK134419 BAE22137 AW495750 BC006611 AAH06611 BC021343 AAH21343 BC025797 AAH25797 BY783212 KJ650202 AIC83990 NM_020581 NP_065606
|
| Function |
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. {ECO:0000250, ECO:0000269|PubMed:15837923, ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:17130448}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:17068295}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17068295}. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
|
| Tissue Specificity |
Predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver. {ECO:0000269|PubMed:10862772}.
|
| Top Pathways |
PPAR signaling pathway
|