| Gene Symbol |
Sema7a
|
| Entrez Gene |
20361
|
| Alt Symbol |
2900057C09Rik, CDw108, H-Sema-L, M-Sema-L, Semal
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
|
| Other Description |
H-Sema K1|Semaphorin K1|sema K1|sema L|semaphorin-7A|semaphorin-K1|semaphorin-L
|
| Swissprots |
O88371 Q9QUR8
|
| Accessions |
EDL25928 Q9QUR8 AB017532 BAA75665 AF030699 AAC34262 AF176670 AAD53118 AK019344 AK156123 BAE33594 BC057875 AAH57875 XM_006510888 XP_006510951 XM_006510889 XP_006510952 NM_011352 NP_035482
|
| Function |
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. {ECO:0000269|PubMed:12879062, ECO:0000269|PubMed:16713976, ECO:0000269|PubMed:17377534}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:17377534}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17377534}; Extracellular side {ECO:0000269|PubMed:17377534}.
|
| Tissue Specificity |
Highly expressed in activated T-cells (at protein level). Highest expression in brain. Lower in heart, thymus, spleen, testis and ovary. The expression increases in late embryonic and postnatal stages. Detected in T-cells. {ECO:0000269|PubMed:16713976, ECO:0000269|PubMed:17377534}.
|
| Top Pathways |
Axon guidance
|