Sema7a

Gene Symbol Sema7a
Entrez Gene 20361
Alt Symbol 2900057C09Rik, CDw108, H-Sema-L, M-Sema-L, Semal
Species Mouse
Gene Type protein-coding
Description sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
Other Description H-Sema K1|Semaphorin K1|sema K1|sema L|semaphorin-7A|semaphorin-K1|semaphorin-L
Swissprots O88371 Q9QUR8
Accessions EDL25928 Q9QUR8 AB017532 BAA75665 AF030699 AAC34262 AF176670 AAD53118 AK019344 AK156123 BAE33594 BC057875 AAH57875 XM_006510888 XP_006510951 XM_006510889 XP_006510952 NM_011352 NP_035482
Function Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. {ECO:0000269|PubMed:12879062, ECO:0000269|PubMed:16713976, ECO:0000269|PubMed:17377534}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17377534}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17377534}; Extracellular side {ECO:0000269|PubMed:17377534}.
Tissue Specificity Highly expressed in activated T-cells (at protein level). Highest expression in brain. Lower in heart, thymus, spleen, testis and ovary. The expression increases in late embryonic and postnatal stages. Detected in T-cells. {ECO:0000269|PubMed:16713976, ECO:0000269|PubMed:17377534}.
Top Pathways Axon guidance

Recombinant Mouse Semaphorin 7A Fc Chimera, CF - 1835-S3-050 from R&D Systems

Category Protein
Source Mouse myeloma cell line, NS0-derived

Recombinant Semaphorin 7A (SEMA7A) - RPB448Mu01 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Semaphorin 7A (SEMA7A) - RPB448Mu02 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Semaphorin 3A (SEMA3A) - RPL917Mu01 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Semaphorin 3A (SEMA3A) - RPL917Mu02 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Mouse Semaphorin-7A(Sema7a) - CSB-YP889544MO CSB-EP889544MO CSB-BP889544MO CSB-MP889544MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Recombinant Mouse Semaphorin 7A Fc Chimera Protein, CF - 1835-S3 from R&D Systems

Category Protein
Prices $329.00
Sizes 50 µg
Source Mouse myeloma cell line, NS0-derived Mouse Semaphorin 7A (Gln45-Ala646) Accession # Q9QUR8 IEGRMDP Mouse IgG 2A (Glu98-Lys330) N-terminus C-terminus
Species Mouse

Recombinant Mouse Sema7a protein, Fc-tagged - Sema7a-191M from Creative Biomart

Category Protein
Source NS0
Species Mouse

Recombinant Mouse SEMA7A Protein - SEMA7A-14877M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse

SEMA7A Recombinant Protein (OPCD06912) - OPCD06912 from Aviva Systems Biology

Category Protein
Source E.coli
Species Mouse

Semaphorin-7A (Sema7a), Recombinant Protein - MBS1451064 from MyBioSource

Category Protein
Prices $1,395.00, $1,395.00, $1,625.00, $1,625.00, $2,350.00, $2,350.00, $2,795.00, $2,795.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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