Sema7a

Gene Symbol Sema7a
Entrez Gene 20361
Alt Symbol 2900057C09Rik, CDw108, H-Sema-L, M-Sema-L, Semal
Species Mouse
Gene Type protein-coding
Description sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
Other Description H-Sema K1|Semaphorin K1|sema K1|sema L|semaphorin-7A|semaphorin-K1|semaphorin-L
Swissprots O88371 Q9QUR8
Accessions EDL25928 Q9QUR8 AB017532 BAA75665 AF030699 AAC34262 AF176670 AAD53118 AK019344 AK156123 BAE33594 BC057875 AAH57875 XM_006510888 XP_006510951 XM_006510889 XP_006510952 NM_011352 NP_035482
Function Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. {ECO:0000269|PubMed:12879062, ECO:0000269|PubMed:16713976, ECO:0000269|PubMed:17377534}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17377534}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17377534}; Extracellular side {ECO:0000269|PubMed:17377534}.
Tissue Specificity Highly expressed in activated T-cells (at protein level). Highest expression in brain. Lower in heart, thymus, spleen, testis and ovary. The expression increases in late embryonic and postnatal stages. Detected in T-cells. {ECO:0000269|PubMed:16713976, ECO:0000269|PubMed:17377534}.
Top Pathways Axon guidance

SEMA7A CRISPR/Cas9 KO Plasmid (m) - sc-422890 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SEMA7A HDR Plasmid (m) - sc-422890-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SEMA7A Double Nickase Plasmid (m) - sc-422890-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SEMA7A Double Nickase Plasmid (m2) - sc-422890-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SEMA7A CRISPR Activation Plasmid (m) - sc-422890-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SEMA7A CRISPR Activation Plasmid (m2) - sc-422890-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SEMA7A Lentiviral Activation Particles (m) - sc-422890-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SEMA7A Lentiviral Activation Particles (m2) - sc-422890-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SEMA7A siRNA (m) - sc-63011 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

SEMA7A shRNA Plasmid (m) - sc-63011-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

SEMA7A shRNA (m) Lentiviral Particles - sc-63011-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU010311 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN40908 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40908 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SEMA7A siRNA (Mouse) - CRM3673 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

SEMA7A - MBS8208354 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse SEMA7A (NM_011352.2) - SHH404416 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Sema7a(NM_011352.2) - SHR214374 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse SEMA7A siRNA - orb283149 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

SEMA7A shRNA Plasmid (Mouse) - CHM3673 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

SEMA7A miRNA 3'UTR clone - MiUTR1M-10543 from Creative biogene

Species Reactivities Mouse
Search more