| Gene Symbol |
ING2
|
| Entrez Gene |
3622
|
| Alt Symbol |
ING1L, p33ING2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
inhibitor of growth family, member 2
|
| Other Description |
ING1Lp|inhibitor of growth 1-like protein|inhibitor of growth protein 2|p32
|
| Swissprots |
B6ZDS1 Q9H160 O95698
|
| Accessions |
AAG11396 EAX04689 EAX04690 Q9H160 AB012853 BAA36419 AB196793 BAF30476 AF053537 AAG11395 AJ006851 CAC20567 AK294310 BAH11731 AK314000 BAG36712 BC030128 AAH30128 BM929984 HQ447773 ADQ32258 XM_011531927 XP_011530229 NM_001291959 NP_001278888 NM_001564 NP_001555
|
| Function |
Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). {ECO:0000269|PubMed:11481424, ECO:0000269|PubMed:12859901}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12859901}. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
|
| Tissue Specificity |
Widely expressed. Higher expressed in colon- cancer tumor than in normal colon tissues. {ECO:0000269|PubMed:10072587}.
|