ING2

Gene Symbol ING2
Entrez Gene 3622
Alt Symbol ING1L, p33ING2
Species Human
Gene Type protein-coding
Description inhibitor of growth family, member 2
Other Description ING1Lp|inhibitor of growth 1-like protein|inhibitor of growth protein 2|p32
Swissprots B6ZDS1 Q9H160 O95698
Accessions AAG11396 EAX04689 EAX04690 Q9H160 AB012853 BAA36419 AB196793 BAF30476 AF053537 AAG11395 AJ006851 CAC20567 AK294310 BAH11731 AK314000 BAG36712 BC030128 AAH30128 BM929984 HQ447773 ADQ32258 XM_011531927 XP_011530229 NM_001291959 NP_001278888 NM_001564 NP_001555
Function Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). {ECO:0000269|PubMed:11481424, ECO:0000269|PubMed:12859901}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12859901}. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
Tissue Specificity Widely expressed. Higher expressed in colon- cancer tumor than in normal colon tissues. {ECO:0000269|PubMed:10072587}.

ING2 (B-5) - sc-271544 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ING2 (B-5): sc-271544. Western blot analysis of ING2 expression in etopside treated MCF7 (A) and etopside treated HeLa (B) whole cell lysates.

ING2 (H-71) - sc-134973 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ING2 (S-20) - sc-67646 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ING2 (S-20): sc-67646. Western blot analysis of ING2 expression in etoposide-treated HL-60 (A), etoposide-treated MCF7 (B) and etoposide-treated HeLa (C) whole cell lysates.

Anti-ING2 antibody - ab169305 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Immunofluorescent analysis of HeLa cells labeling ING2 with purified version of ab169305 at 10µg/ml. Antibody purification with Protein A will be needed prior to use.

Anti-ING2 antibody - ab169332 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-ING2 antibody (ab169332) at 1/500 dilutionLane 1 : ING2-transfected 293T cell lysateLane 2 : Non-transfected cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-ING2 antibody - ab2643 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-ING2 antibody (ab2643) at 2 µg/ml + HepG2 lysate (RIPA buffer, 35µg total protein per lane).

Anti-ING2 antibody - ab197762 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ING2 antibody (ab197762) at 1/425 dilutionLane 1 : Lovo cell lysateLane 2 : Human liver cancer tissue lysateLane 3 : Mouse kidney tissue lysateLysates/proteins at 40 µg per lane.

Anti-ING2 antibody - ab174200 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ING2 antibody (ab174200) at 1/100 dilution + ZR-75-1 cell line lysate at 35 µg

Anti-ING2 antibody [EPR4597] - ab109504 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4597
ICC/IF image of ab109504 stained MCF-7 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab109504 at 1/100 dilution overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-ING2 antibody [EPR4597-5] - ab174305 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4597-5
All lanes : Anti-ING2 antibody [EPR4597-5] (ab174305) at 1/1000 dilutionLane 1 : Hela cell lysateLane 2 : HT-1080 cell lysateLane 3 : Saos-2 cell lysateLysates/proteins at 10 µg per lane.

Anti-ING2 Antibody (aa25-74) - LS-C117057 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ING2 antibody LS-C117057 Western blot of COLO205 cell lysate.

Anti-ING2 Antibody (aa22-200) - LS-C178886 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ING2 Antibody (aa267-280) - LS-C55006 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining (2 ug/ml) of HepG2 lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 12 hour. Detected by Western blot of chemiluminescence.

Anti-ING2 Antibody (aa112-141, AP) - LS-C260237 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ING2 Antibody (aa112-141) - LS-C157837 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ING2 Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The ING2 antibody detected the ING2 protein (arrow).

Anti-ING2 Antibody (aa112-141, APC) - LS-C260239 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ING2 Antibody (aa112-141, Biotin) - LS-C260240 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ING2 Antibody (clone 2G3) - LS-C175426 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2G3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ING2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ING2.

Anti-ING2 Antibody (clone 2F5) - LS-C175419 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2F5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ING2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ING2.

Anti-ING2 Antibody (aa112-141, FITC) - LS-C260241 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ING2 Antibody (aa112-141, PE) - LS-C260243 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ING2 Antibody (aa112-141, Azide-free, HRP) - LS-C260242 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ING2 Antibody (aa111-141) - LS-C322244 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ING2 Antibody (clone 4G10) - LS-C175429 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4G10
Western blot of extracts (35 ug) from 9 different cell lines by using g anti-ING2 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).

Anti-ING2 Antibody (clone 1D1) - LS-C197535 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D1
Immunofluorescence of monoclonal antibody to ING2 on HeLa cell . [antibody concentration 10 ug/ml]
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