JAK2

Gene Symbol	JAK2
Entrez Gene	3717
Alt Symbol	JTK10, THCYT3
Species	Human
Gene Type	protein-coding
Description	Janus kinase 2
Other Description	JAK-2|Janus kinase 2 (a protein tyrosine kinase)|tyrosine-protein kinase JAK2
Swissprots	O14636 O60674 O75297
Accessions	AAY16348 ABK91947 ABM69254 ABX71217 EAW58774 O60674 AF001362 AAC23653 AF005216 AAB82092 AF058925 AAC23982 AI923337 AK292525 BAF85214 AK302618 BAG63863 AK308668 AY973034 AAY22962 BC039695 AAH39695 BC043187 NM_004972 NP_004963
Function	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosp
Subcellular Location	Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19783980}. Nucleus {ECO:0000269|PubMed:19783980}.
Tissue Specificity	Ubiquitously expressed throughout most tissues. {ECO:0000269|PubMed:16424865}.
Top Pathways	Toxoplasmosis, Leishmaniasis, Jak-STAT signaling pathway, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan® Jak2 Kinase Assay Kit - 7752 from Cell Signaling Technology Category Assay Kit

Phosphotyrosine JAK2 / Tyrosine-protein Kinase JAK2 ELISA Kit - RAB0971 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Tyrosine-protein kinase JAK2 (JAK2), Human, ELISA Kit - E01T0620 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Tyrosine-protein kinase JAK2, JAK2, Human, ELISA Kit - E9140h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.156-10 ng/mL

Human Phospho-JAK2 (Y1007/1008) ELISA - PEL-JAK2-Y1007 from RayBiotech Category ELISA Kit Prices $481.00, $866.00, $1,924.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

JAK2, ELISA Kit - MBS2515858 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 75pg/mL Range 125-8000pg/mL

Janus Kinase, ELISA Kit - MBS751620 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS750608 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS005651 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS755226 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Janus Kinase, ELISA Kit - MBS755483 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Janus Kinase, ELISA Kit - MBS030257 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS028739 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS108100 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS045391 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS748133 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS043373 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS062830 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS747892 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS746362 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS754554 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase, ELISA Kit - MBS028286 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

JAK2 Colorimetric Cell-Based ELISA Kit - CB5385 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

JAK2 (Phospho-Tyr570) Colorimetric Cell-Based ELISA Kit - CBP1168 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

JAK2 (Phospho-Tyr221) Colorimetric Cell-Based ELISA Kit - CBP1593 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

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