| Gene Symbol | JAK2 |
|---|---|
| Entrez Gene | 3717 |
| Alt Symbol | JTK10, THCYT3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Janus kinase 2 |
| Other Description | JAK-2|Janus kinase 2 (a protein tyrosine kinase)|tyrosine-protein kinase JAK2 |
| Swissprots | O14636 O60674 O75297 |
| Accessions | AAY16348 ABK91947 ABM69254 ABX71217 EAW58774 O60674 AF001362 AAC23653 AF005216 AAB82092 AF058925 AAC23982 AI923337 AK292525 BAF85214 AK302618 BAG63863 AK308668 AY973034 AAY22962 BC039695 AAH39695 BC043187 NM_004972 NP_004963 |
| Function | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosp |
| Subcellular Location | Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19783980}. Nucleus {ECO:0000269|PubMed:19783980}. |
| Tissue Specificity | Ubiquitously expressed throughout most tissues. {ECO:0000269|PubMed:16424865}. |
| Top Pathways | Toxoplasmosis, Leishmaniasis, Jak-STAT signaling pathway, Measles, Influenza A |