JAK2

Gene Symbol	JAK2
Entrez Gene	3717
Alt Symbol	JTK10, THCYT3
Species	Human
Gene Type	protein-coding
Description	Janus kinase 2
Other Description	JAK-2|Janus kinase 2 (a protein tyrosine kinase)|tyrosine-protein kinase JAK2
Swissprots	O14636 O60674 O75297
Accessions	AAY16348 ABK91947 ABM69254 ABX71217 EAW58774 O60674 AF001362 AAC23653 AF005216 AAB82092 AF058925 AAC23982 AI923337 AK292525 BAF85214 AK302618 BAG63863 AK308668 AY973034 AAY22962 BC039695 AAH39695 BC043187 NM_004972 NP_004963
Function	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosp
Subcellular Location	Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19783980}. Nucleus {ECO:0000269|PubMed:19783980}.
Tissue Specificity	Ubiquitously expressed throughout most tissues. {ECO:0000269|PubMed:16424865}.
Top Pathways	Toxoplasmosis, Leishmaniasis, Jak-STAT signaling pathway, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human JAK2 full length protein - ab42619 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human JAK2 full length protein - ab42621 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human JAK2 protein fragment - ab175151 from Abcam Category Protein Source E. coli Species Human

Recombinant Human Jak2 Protein - NBP2-23154 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

Jak2 Recombinant Protein - P4706 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Jak2 Recombinant Protein - P4708 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Jak2 Peptide - P0243 from Novus Biologicals Category Peptide Species Human

JAK2-Antibody-C-term-Blocking-Peptide - BP1125b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

JAK2-Antibody-Center-Blocking-Peptide - BP14491c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human JAK2 protein - orb244313 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

JAK2 peptide - orb217493 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey, Drosophila

JAK2 peptide - orb72899 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

JAK2 protein (His tag) - 80R-3620 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

Human Janus Kinase 2 Protein - abx067577 from Abbexa Category Protein Source E.coli Species Human

JAK2 (phospho-Tyr1007) Blocking Peptide - abx062822 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Pig, Zebrafish

JAK2 (phospho-Tyr570) Blocking Peptide - abx062823 from Abbexa Category Peptide Species Human, Mouse, Rat, Dog, Monkey, Pig, Rabbit

JAK2 Blocking Peptide - abx062824 from Abbexa Category Peptide Species Human, Mouse, Rat, Dog, Monkey, Pig, Rabbit

Tyrosine-protein kinase JAK2 (1014-1132, His-tag) - AR51307PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Tyrosine-protein kinase JAK2 (1014-1132, His-tag) - AR51307PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Tyrosine-protein kinase JAK2 - P4706 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

Tyrosine-protein kinase JAK2 - P4708 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

Tyrosine-protein kinase JAK2 - P5722 from Acris Antibodies Category Protein Prices $1,180.00 Sizes 5 µg Species Human

Tyrosine-protein kinase JAK2 - P5723 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

Tyrosine-protein kinase JAK2 - P5762 from Acris Antibodies Category Protein Prices $1,180.00 Sizes 5 µg Species Human

JAK2, 1014-1132aa, Human, His tag, E.coli - 01-P2487 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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