JAK2

Gene Symbol	JAK2
Entrez Gene	3717
Alt Symbol	JTK10, THCYT3
Species	Human
Gene Type	protein-coding
Description	Janus kinase 2
Other Description	JAK-2|Janus kinase 2 (a protein tyrosine kinase)|tyrosine-protein kinase JAK2
Swissprots	O14636 O60674 O75297
Accessions	AAY16348 ABK91947 ABM69254 ABX71217 EAW58774 O60674 AF001362 AAC23653 AF005216 AAB82092 AF058925 AAC23982 AI923337 AK292525 BAF85214 AK302618 BAG63863 AK308668 AY973034 AAY22962 BC039695 AAH39695 BC043187 NM_004972 NP_004963
Function	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosp
Subcellular Location	Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19783980}. Nucleus {ECO:0000269|PubMed:19783980}.
Tissue Specificity	Ubiquitously expressed throughout most tissues. {ECO:0000269|PubMed:16424865}.
Top Pathways	Toxoplasmosis, Leishmaniasis, Jak-STAT signaling pathway, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Jak2 siRNA I - 6235 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

JAK2 CRISPR/Cas9 KO Plasmid (h) - sc-400246 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK2 HDR Plasmid (h) - sc-400246-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK2 Double Nickase Plasmid (h) - sc-400246-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK2 Double Nickase Plasmid (h2) - sc-400246-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK2 CRISPR Activation Plasmid (h) - sc-400246-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK2 CRISPR Activation Plasmid (h2) - sc-400246-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK2 Lentiviral Activation Particles (h) - sc-400246-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK2 Lentiviral Activation Particles (h2) - sc-400246-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK2 siRNA (h) - sc-39099 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

JAK2 shRNA Plasmid (h) - sc-39099-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

JAK2 shRNA (h) Lentiviral Particles - sc-39099-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Jak2 RNAi - H00003717-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU130881 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK1008 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1007 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1006 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1537 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1537 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

JAK2 siRNA (Human) - CRH2503 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

JAK2, siRNA - MBS8218171 from MyBioSource Category siRNA Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human JAK2 (NM_004972.3) - SHH321923 from Creative biogene Category siRNA Species Reactivities Human

Human JAK2 siRNA - orb263005 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

JAK2 shRNA Plasmid (Human) - CHH2503 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

JAK2 miRNA 3'UTR clone - MiUTR3H-01246 from Creative biogene Species Reactivities Human

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