LNPEP

Gene Symbol LNPEP
Entrez Gene 4012
Alt Symbol CAP, IRAP, P-LAP, PLAP
Species Human
Gene Type protein-coding
Description leucyl/cystinyl aminopeptidase
Other Description AT (4) receptor|angiotensin IV receptor|cystinyl aminopeptidase|insulin-regulated aminopeptidase|insulin-regulated membrane aminopeptidase|insulin-responsive aminopeptidase|leucyl-cystinyl aminopeptidase|otase|oxytocinase|placental leucine aminopeptidase|vasopressinase
Swissprots Q9TNQ3 Q9UIQ6 Q59H76 Q15145 Q9TNQ2 Q9UIQ7 O00769
Accessions CAB61646 CAB94753 EAW96084 Q9UIQ6 AB208883 BAD92120 AK096804 AK314226 BAG36898 BC028692 BC111718 BC113117 BC160010 AAI60010 BG622952 BQ923659 D50810 BAA09436 U62768 AAB66672 U62769 AAB66673 NM_005575 NP_005566 NM_175920 NP_787116
Function Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11389728}; Single-pass type II membrane protein {ECO:0000269|PubMed:11389728}. Note=In brain only the membrane- bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.
Tissue Specificity Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:8550619, ECO:0000269|PubMed:9177475}.
Top Pathways Renin-angiotensin system

IRAP (D7C5) XP ® Rabbit mAb - 6918 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7C5
Western blot analysis of C2C12 cells using IRAP (D7C5) XP ® Rabbit mAb.

IRAP Antibody - 3808 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from C2C12 cells using IRAP Antibody.

IRAP (F-5) - sc-365300 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IRAP (F-5): sc-365300. Western blot analysis of IRAP expression in C2C12 whole cell lysate.

IRAP (E-12) - sc-365051 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IRAP (E-12): sc-365051. Western blot analysis of IRAP expression in Ramos (A) and Raji (B) whole cell lysates.

IRAP (E-14) - sc-107642 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IRAP (H-133) - sc-135229 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IRAP (H-133): sc-135229. Western blot analysis of IRAP expression in mouse brain tissue extract.

IRAP (N-12) - sc-107643 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Leucyl-cystinyl aminopeptidase antibody - ab107450 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Leucyl-cystinyl aminopeptidase antibody (ab107450) at 1/100 dilution + HL60 cell lysate at 35 µg

Anti-LNPEP Antibody - LS-C130300 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LNPEP Antibody (Extracellular Domain) - LS-C8257 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-LNPEP Antibody (Extracellular Domain) - LS-C8258 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-LNPEP Antibody - LS-C143812 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-LNPEP Antibody (aa23-52, APC) - LS-C262040 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LNPEP Antibody (aa23-52, Biotin) - LS-C262041 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LNPEP Antibody (aa23-52, AP) - LS-C262039 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LNPEP Antibody (aa23-52, FITC) - LS-C262042 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LNPEP Antibody (aa23-52, Azide-free, HRP) - LS-C262043 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LNPEP Antibody (aa23-52, PE) - LS-C262045 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LNPEP Antibody (aa1-50) - LS-C291002 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Oxytocinase by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN buffer from Jurkat cells. Antibodies: Affinity purified rabbit anti-Oxytocinase antibody used for IP at 6 ug per reaction. Oxytocinase was also immunoprecipitated by rabbit anti-Oxytocinase antibody BL16227. For blotting immunoprecipitated Oxytocinase, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-LNPEP Antibody (aa23-52) - LS-C165817 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
LNPEP antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-LNPEP Antibody (C-Terminus) IHC-plus™ - LS-B8873 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LNPEP antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Leucyl-cystinyl Aminopeptidase/LNPEP Antibody - AF6386 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line. PVDF Membrane was probed with 1 µg/mL of Human Leucyl-cystinyl Aminopeptidase/LNPEP Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6386) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Leucyl-cystinyl Aminopeptidase/LNPEP at approximately 170 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

Leucyl-cystinyl Aminopeptidase/LNPEP Antibody - NBP2-32111 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Leucyl-cystinyl Aminopeptidase/LNPEP Antibody [NBP2-32111] - Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN buffer from Jurkat cells. Antibodies: Affinity purified rabbit anti-Oxytocinase antibody NBP2-32111 used for IP at 6 ug per reaction. Oxytocinase was also immunoprecipitated by rabbit anti-Oxytocinase antibody BL16227. For blotting immunoprecipitated Oxytocinase, NBP2-32111 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Leucyl-cystinyl Aminopeptidase/LNPEP Antibody (SP15) - NBP1-22840 from Novus Biologicals

Prices $329.00
Sizes 6 ml
Host Rabbit
Clonality Monoclonal
Clone SP15

Leucyl-cystinyl Aminopeptidase/LNPEP Antibody - NBP1-92071 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Search more