LNPEP

Gene Symbol	LNPEP
Entrez Gene	4012
Alt Symbol	CAP, IRAP, P-LAP, PLAP
Species	Human
Gene Type	protein-coding
Description	leucyl/cystinyl aminopeptidase
Other Description	AT (4) receptor|angiotensin IV receptor|cystinyl aminopeptidase|insulin-regulated aminopeptidase|insulin-regulated membrane aminopeptidase|insulin-responsive aminopeptidase|leucyl-cystinyl aminopeptidase|otase|oxytocinase|placental leucine aminopeptidase|vasopressinase
Swissprots	Q9TNQ3 Q9UIQ6 Q59H76 Q15145 Q9TNQ2 Q9UIQ7 O00769
Accessions	CAB61646 CAB94753 EAW96084 Q9UIQ6 AB208883 BAD92120 AK096804 AK314226 BAG36898 BC028692 BC111718 BC113117 BC160010 AAI60010 BG622952 BQ923659 D50810 BAA09436 U62768 AAB66672 U62769 AAB66673 NM_005575 NP_005566 NM_175920 NP_787116
Function	Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:11389728}; Single-pass type II membrane protein {ECO:0000269|PubMed:11389728}. Note=In brain only the membrane- bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.
Tissue Specificity	Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:8550619, ECO:0000269|PubMed:9177475}.
Top Pathways	Renin-angiotensin system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LNPEP cDNA clone(NM_175920.3) - CDFG010808 from Creative Biomart Species Human Accession NM_175920.3

Human LNPEP cDNA clone(NM_005575.2) - CDFH010478 from Creative Biomart Species Human Accession NM_005575.2

Human LNPEP ORF clone(NM_005575.2) - CDCL185177 from Creative Biomart Species Human Accession NM_005575.2

Human LNPEP ORF clone(NM_005575.2) - CDCH387608 from Creative Biomart Species Human Accession NM_005575.2

Human LNPEP ORF Clone(NM_005575.2) - CDCL168777 from Creative Biomart Species Human Accession NM_005575.2

Human LNPEP ORF Clone(NM_005575.2) - CDCR290820 from Creative Biomart Species Human Accession NM_005575.2

Human LNPEP ORF Clone(NM_005575.2) - CDCR290821 from Creative Biomart Species Human Accession NM_005575.2

Human LNPEP ORF Clone(NM_005575.2) - CDCR290822 from Creative Biomart Species Human Accession NM_005575.2

Human LNPEP ORF Clone(NM_175920.3) - CDCR382598 from Creative Biomart Species Human Accession NM_175920.3

Human LNPEP ORF Clone(NM_175920.3) - CDCR382599 from Creative Biomart Species Human Accession NM_175920.3

Human LNPEP Gene ORF cDNA clone in cloning vector - HG13683-G from Sino Biological Species Human

Human LNPEP Gene ORF cDNA clone expression plasmid - HG13683-UT from Sino Biological Species Human

Human LNPEP Gene ORF cDNA clone expression plasmid, C-His tag - HG13683-CH from Sino Biological Species Human

Human LNPEP Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13683-ACG from Sino Biological Species Human

Human LNPEP Gene ORF cDNA clone expression plasmid, N-HA tag - HG13683-NY from Sino Biological Species Human

Human LNPEP Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13683-ACR from Sino Biological Species Human

Human LNPEP Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13683-NF from Sino Biological Species Human

Human LNPEP Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13683-NM from Sino Biological Species Human

Human LNPEP Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13683-CF from Sino Biological Species Human

Human LNPEP Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13683-CM from Sino Biological Species Human

Human LNPEP Gene ORF cDNA clone expression plasmid, N-His tag - HG13683-NH from Sino Biological Species Human

Human LNPEP Gene ORF cDNA clone expression plasmid, C-HA tag - HG13683-CY from Sino Biological Species Human

Human LNPEP ORF clone(NM_005575.2) - CDCL185177 from Creative biogene Species Human

Human LNPEP ORF clone (NM_175920.3) - CDCL127781 from Creative biogene Species Human

Human LNPEP cDNA Clone(NM_175920.3) - CDFG010808 from Creative biogene Species Human

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