LNPEP

Gene Symbol	LNPEP
Entrez Gene	4012
Alt Symbol	CAP, IRAP, P-LAP, PLAP
Species	Human
Gene Type	protein-coding
Description	leucyl/cystinyl aminopeptidase
Other Description	AT (4) receptor|angiotensin IV receptor|cystinyl aminopeptidase|insulin-regulated aminopeptidase|insulin-regulated membrane aminopeptidase|insulin-responsive aminopeptidase|leucyl-cystinyl aminopeptidase|otase|oxytocinase|placental leucine aminopeptidase|vasopressinase
Swissprots	Q9TNQ3 Q9UIQ6 Q59H76 Q15145 Q9TNQ2 Q9UIQ7 O00769
Accessions	CAB61646 CAB94753 EAW96084 Q9UIQ6 AB208883 BAD92120 AK096804 AK314226 BAG36898 BC028692 BC111718 BC113117 BC160010 AAI60010 BG622952 BQ923659 D50810 BAA09436 U62768 AAB66672 U62769 AAB66673 NM_005575 NP_005566 NM_175920 NP_787116
Function	Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:11389728}; Single-pass type II membrane protein {ECO:0000269|PubMed:11389728}. Note=In brain only the membrane- bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.
Tissue Specificity	Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:8550619, ECO:0000269|PubMed:9177475}.
Top Pathways	Renin-angiotensin system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LNPEP ELISA Kit (Sandwich ELISA) - LS-F7808 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.062 ng/ml Range 0.156-10 ng/ml

Human LNPEP ELISA Kit (Sandwich ELISA) - LS-F11924 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 0.156-10 ng/ml

Human LNPEP ELISA Kit - abx152216 from Abbexa Category ELISA Kit Sensitivity 0.61 ng/ml Range 1.563 ng/ml - 100 ng/ml

Leucyl-Cystinyl aminopeptidase, Human, ELISA Kit - E01L0290 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Leucyl-cystinyl aminopeptidase, LNPEP, Human, ELISA Kit - E13522h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.78-50 ng/mL

Leucyl Cystinyl aminopeptidase, ELISA Kit - MBS749486 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl aminopeptidase, ELISA Kit - MBS748298 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Leucyl-Cystinyl aminopeptidase, ELISA Kit - MBS750091 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl Aminopeptidase, ELISA Kit - MBS057360 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl aminopeptidase, ELISA Kit - MBS749844 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl Aminopeptidase, ELISA Kit - MBS041755 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl aminopeptidase, ELISA Kit - MBS750628 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl Aminopeptidase, ELISA Kit - MBS026429 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl Aminopeptidase, ELISA Kit - MBS041792 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl Aminopeptidase, ELISA Kit - MBS071234 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl aminopeptidase, ELISA Kit - MBS748367 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl Aminopeptidase, ELISA Kit - MBS011347 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl Aminopeptidase, ELISA Kit - MBS012885 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl Aminopeptidase, ELISA Kit - MBS007258 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl Aminopeptidase, ELISA Kit - MBS102517 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl Aminopeptidase, ELISA Kit - MBS009591 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 U/L. Range 6.25 U/L - 200 U/L.

Leucyl-Cystinyl Aminopeptidase, ELISA Kit - MBS033147 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl Aminopeptidase, ELISA Kit - MBS036476 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl aminopeptidase, ELISA Kit - MBS746378 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Leucyl-Cystinyl aminopeptidase, ELISA Kit - MBS745869 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

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