| Gene Symbol |
LNPEP
|
| Entrez Gene |
4012
|
| Alt Symbol |
CAP, IRAP, P-LAP, PLAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucyl/cystinyl aminopeptidase
|
| Other Description |
AT (4) receptor|angiotensin IV receptor|cystinyl aminopeptidase|insulin-regulated aminopeptidase|insulin-regulated membrane aminopeptidase|insulin-responsive aminopeptidase|leucyl-cystinyl aminopeptidase|otase|oxytocinase|placental leucine aminopeptidase|vasopressinase
|
| Swissprots |
Q9TNQ3 Q9UIQ6 Q59H76 Q15145 Q9TNQ2 Q9UIQ7 O00769
|
| Accessions |
CAB61646 CAB94753 EAW96084 Q9UIQ6 AB208883 BAD92120 AK096804 AK314226 BAG36898 BC028692 BC111718 BC113117 BC160010 AAI60010 BG622952 BQ923659 D50810 BAA09436 U62768 AAB66672 U62769 AAB66673 NM_005575 NP_005566 NM_175920 NP_787116
|
| Function |
Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:11389728}; Single-pass type II membrane protein {ECO:0000269|PubMed:11389728}. Note=In brain only the membrane- bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.
|
| Tissue Specificity |
Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:8550619, ECO:0000269|PubMed:9177475}.
|
| Top Pathways |
Renin-angiotensin system
|
![Western Blot: Leucyl-cystinyl aminopeptidase Overexpression Lysate (Adult Normal) [NBL1-12570] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Leucyl-cystinyl aminopeptidase.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/685_Leucyl-cystinyl%2520aminopeptidase%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12570-img0002.jpg)