Gene Symbol | DPH3 |
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Entrez Gene | 285381 |
Alt Symbol | DELGIP, DELGIP1, DESR1, DPH3A, KTI11, ZCSL2 |
Species | Human |
Gene Type | protein-coding |
Description | diphthamide biosynthesis 3 |
Other Description | CSL-type zinc finger-containing protein 2|DPH3 homolog|DPH3 homolog (KTI11, S. cerevisiae)|DPH3, KTI11 homolog|DPH3A, KTI11 homolog A|Del-GEF interacting protein|deafness locus putative guanine nucleotide exchange factor interacting protein 1|delGEF-interacting protein 1|diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1|zinc finger, CSL domain containing 2|zinc finger, CSL-type containing 2 |
Swissprots | Q96FX2 |
Accessions | EAW64268 EAW64269 Q96FX2 AK022970 AK023203 AK092040 AK311618 BC010181 AAH10181 BC073931 BC094863 DA447430 DA875039 JF432467 ADZ15684 NM_001047434 NP_001040899 NM_206831 NP_996662 |
Function | Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14980502}. Nucleus {ECO:0000269|PubMed:14980502}. |
Tissue Specificity | Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung. {ECO:0000269|PubMed:14527407, ECO:0000269|PubMed:14980502}. |
ZCSL1/2 (G-15) - sc-67996 from Santa Cruz Biotechnology
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ZCSL2 (H-53) - sc-382449 from Santa Cruz Biotechnology
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Anti-DPH3 antibody - ab122265 from Abcam
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DPH3 Antibody - NBP1-84276 from Novus Biologicals
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Anti-DPH3 antibody produced in rabbit - HPA035287 from Sigma-Aldrich
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Anti-DPH3 (aa 11-81) polyclonal antibody - DPABH-20559 from Creative Diagnostics
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DPH3 Antibody,HRP conjugated - CSB-PA822214LB01HU from Cusabio
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DPH3 Antibody,FITC conjugated - CSB-PA822214LC01HU from Cusabio
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DPH3 Antibody,Biotin conjugated - CSB-PA822214LD01HU from Cusabio
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DPH3 Antibody - CSB-PA822214LA01HU from Cusabio
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DPH3 antibody (FITC) - orb187505 from Biorbyt
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DPH3 antibody (HRP) - orb354650 from Biorbyt
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DPH3, Polyclonal Antibody - MBS1493547 from MyBioSource
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DPH3, Polyclonal Antibody - MBS1493854 from MyBioSource
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DPH3, Polyclonal Antibody - MBS1493467 from MyBioSource
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DPH3, Polyclonal Antibody - MBS1491967 from MyBioSource
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Anti-DPH3 Antibody (HRP) - LS-C378229 from LifeSpan Bioscience
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Anti-DPH3 Antibody - LS-C378228 from LifeSpan Bioscience
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Anti-DPH3 Antibody (Biotin) - LS-C378232 from LifeSpan Bioscience
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Anti-DPH3 Antibody (FITC) - LS-C378231 from LifeSpan Bioscience
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