Gene Symbol | DPH3 |
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Entrez Gene | 285381 |
Alt Symbol | DELGIP, DELGIP1, DESR1, DPH3A, KTI11, ZCSL2 |
Species | Human |
Gene Type | protein-coding |
Description | diphthamide biosynthesis 3 |
Other Description | CSL-type zinc finger-containing protein 2|DPH3 homolog|DPH3 homolog (KTI11, S. cerevisiae)|DPH3, KTI11 homolog|DPH3A, KTI11 homolog A|Del-GEF interacting protein|deafness locus putative guanine nucleotide exchange factor interacting protein 1|delGEF-interacting protein 1|diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1|zinc finger, CSL domain containing 2|zinc finger, CSL-type containing 2 |
Swissprots | Q96FX2 |
Accessions | EAW64268 EAW64269 Q96FX2 AK022970 AK023203 AK092040 AK311618 BC010181 AAH10181 BC073931 BC094863 DA447430 DA875039 JF432467 ADZ15684 NM_001047434 NP_001040899 NM_206831 NP_996662 |
Function | Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14980502}. Nucleus {ECO:0000269|PubMed:14980502}. |
Tissue Specificity | Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung. {ECO:0000269|PubMed:14527407, ECO:0000269|PubMed:14980502}. |
Recombinant Human DPH3 homolog(DPH3) - CSB-YP822214HU CSB-EP822214HU CSB-BP822214HU CSB-MP822214HU from Cusabio
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ZCSL2 (transcript variant 1) - TP304203 from Acris Antibodies
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DPH3 Recombinant Protein Antigen - NBP1-84276PEP from Novus Biologicals
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DPH3 Peptide, Human - M34GP04508H from Creative Peptides
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DPH3 homolog (DPH3), Recombinant Protein - MBS1457028 from MyBioSource
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DPH3 homolog (DPH3), Recombinant Protein - MBS1337507 from MyBioSource
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