Gene Symbol | DPH3 |
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Entrez Gene | 285381 |
Alt Symbol | DELGIP, DELGIP1, DESR1, DPH3A, KTI11, ZCSL2 |
Species | Human |
Gene Type | protein-coding |
Description | diphthamide biosynthesis 3 |
Other Description | CSL-type zinc finger-containing protein 2|DPH3 homolog|DPH3 homolog (KTI11, S. cerevisiae)|DPH3, KTI11 homolog|DPH3A, KTI11 homolog A|Del-GEF interacting protein|deafness locus putative guanine nucleotide exchange factor interacting protein 1|delGEF-interacting protein 1|diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1|zinc finger, CSL domain containing 2|zinc finger, CSL-type containing 2 |
Swissprots | Q96FX2 |
Accessions | EAW64268 EAW64269 Q96FX2 AK022970 AK023203 AK092040 AK311618 BC010181 AAH10181 BC073931 BC094863 DA447430 DA875039 JF432467 ADZ15684 NM_001047434 NP_001040899 NM_206831 NP_996662 |
Function | Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14980502}. Nucleus {ECO:0000269|PubMed:14980502}. |
Tissue Specificity | Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung. {ECO:0000269|PubMed:14527407, ECO:0000269|PubMed:14980502}. |
ZCSL2 CRISPR/Cas9 KO Plasmid (h) - sc-416814 from Santa Cruz Biotechnology
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ZCSL2 HDR Plasmid (h) - sc-416814-HDR from Santa Cruz Biotechnology
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ZCSL2 Double Nickase Plasmid (h) - sc-416814-NIC from Santa Cruz Biotechnology
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ZCSL2 Double Nickase Plasmid (h2) - sc-416814-NIC-2 from Santa Cruz Biotechnology
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ZCSL2 CRISPR Activation Plasmid (h) - sc-416814-ACT from Santa Cruz Biotechnology
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ZCSL2 CRISPR Activation Plasmid (h2) - sc-416814-ACT-2 from Santa Cruz Biotechnology
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ZCSL2 Lentiviral Activation Particles (h) - sc-416814-LAC from Santa Cruz Biotechnology
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ZCSL2 Lentiviral Activation Particles (h2) - sc-416814-LAC-2 from Santa Cruz Biotechnology
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ZCSL2 siRNA (h) - sc-106708 from Santa Cruz Biotechnology
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ZCSL2 shRNA Plasmid (h) - sc-106708-SH from Santa Cruz Biotechnology
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ZCSL2 shRNA (h) Lentiviral Particles - sc-106708-V from Santa Cruz Biotechnology
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DPH3 RNAi - H00285381-R01 from Novus Biologicals
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MISSION® esiRNA - EHU014351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7452 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7452 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02497 from Sigma-Aldrich
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DPH3 siRNA (Human) - CRJ7094 from Cohesion Biosciences
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DPH3 - MBS8221909 from MyBioSource
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shRNA set against Human DPH3 (NM_206831.2) - SHH280577 from Creative biogene
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Human DPH3 siRNA - orb277595 from Biorbyt
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DPH3 shRNA Plasmid (Human) - CHJ7094 from Cohesion Biosciences
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DPH3 miRNA 3'UTR clone - MiUTR4H-TG02846 from Creative biogene
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