| Gene Symbol |
DPH3
|
| Entrez Gene |
285381
|
| Alt Symbol |
DELGIP, DELGIP1, DESR1, DPH3A, KTI11, ZCSL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
diphthamide biosynthesis 3
|
| Other Description |
CSL-type zinc finger-containing protein 2|DPH3 homolog|DPH3 homolog (KTI11, S. cerevisiae)|DPH3, KTI11 homolog|DPH3A, KTI11 homolog A|Del-GEF interacting protein|deafness locus putative guanine nucleotide exchange factor interacting protein 1|delGEF-interacting protein 1|diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1|zinc finger, CSL domain containing 2|zinc finger, CSL-type containing 2
|
| Swissprots |
Q96FX2
|
| Accessions |
EAW64268 EAW64269 Q96FX2 AK022970 AK023203 AK092040 AK311618 BC010181 AAH10181 BC073931 BC094863 DA447430 DA875039 JF432467 ADZ15684 NM_001047434 NP_001040899 NM_206831 NP_996662
|
| Function |
Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:14980502}. Nucleus {ECO:0000269|PubMed:14980502}.
|
| Tissue Specificity |
Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung. {ECO:0000269|PubMed:14527407, ECO:0000269|PubMed:14980502}.
|