| Gene Symbol |
MCL1
|
| Entrez Gene |
4170
|
| Alt Symbol |
BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myeloid cell leukemia 1
|
| Other Description |
bcl-2-like protein 3|bcl-2-related protein EAT/mcl1|induced myeloid leukemia cell differentiation protein Mcl-1|myeloid cell leukemia ES|myeloid cell leukemia sequence 1 (BCL2-related)
|
| Swissprots |
Q9UHR8 Q07820 Q9HD91 D3DV04 B2R6B2 Q9UNJ1 Q9NRQ4 D3DV03 Q9NRQ3 Q9UHR9 Q9UHR7
|
| Accessions |
AAF64255 AAF64256 AAF74821 AAG00896 AAY68220 EAW53538 EAW53539 EAW53540 EAW53541 Q07820 AA453505 AF118124 AAD13299 AF118276 AAF15309 AF118277 AAF15310 AF118278 AAF15311 AF203373 AAG00904 AK294462 BAG57694 AK297217 BAG59700 AK300499 BAG62213 AK304775 BAG65530 AK312508 BAG35409 AK316267 BAH14638 BC017197 AAH17197 BC071897 AAH71897 BC107735 AAI07736 BT006640 AAP35286 CA421486 DQ890628 ABM92245 DQ893795 ABM84721 FJ917536 ACV83304 L08246 NM_001197320 NP_001184249 NM_021960 NP_068779 NM_182763 NP_877495
|
| Function |
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
|
| Top Pathways |
PI3K-Akt signaling pathway, MicroRNAs in cancer
|