MCL1

Gene Symbol MCL1
Entrez Gene 4170
Alt Symbol BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
Species Human
Gene Type protein-coding
Description myeloid cell leukemia 1
Other Description bcl-2-like protein 3|bcl-2-related protein EAT/mcl1|induced myeloid leukemia cell differentiation protein Mcl-1|myeloid cell leukemia ES|myeloid cell leukemia sequence 1 (BCL2-related)
Swissprots Q9UHR8 Q07820 Q9HD91 D3DV04 B2R6B2 Q9UNJ1 Q9NRQ4 D3DV03 Q9NRQ3 Q9UHR9 Q9UHR7
Accessions AAF64255 AAF64256 AAF74821 AAG00896 AAY68220 EAW53538 EAW53539 EAW53540 EAW53541 Q07820 AA453505 AF118124 AAD13299 AF118276 AAF15309 AF118277 AAF15310 AF118278 AAF15311 AF203373 AAG00904 AK294462 BAG57694 AK297217 BAG59700 AK300499 BAG62213 AK304775 BAG65530 AK312508 BAG35409 AK316267 BAH14638 BC017197 AAH17197 BC071897 AAH71897 BC107735 AAI07736 BT006640 AAP35286 CA421486 DQ890628 ABM92245 DQ893795 ABM84721 FJ917536 ACV83304 L08246 NM_001197320 NP_001184249 NM_021960 NP_068779 NM_182763 NP_877495
Function Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}.
Subcellular Location Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
Top Pathways PI3K-Akt signaling pathway, MicroRNAs in cancer

Phospho-Mcl-1 (Ser64) Antibody - 13297 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HCT 116 and KARPAS-299 cells, untreated (-) or treated with MG-132 #2194 (10 μM, overnight; +) using Phospho-Mcl-1 (Ser64) Antibody (left). Phospho-specificity is demonstrated by antibody competition with peptides specific for phospho-Mcl-1 (Ser64) (middle) or non-phospho-Mcl-1 (Ser64) (right).

Phospho-Mcl-1 (Ser159/Thr163) Antibody - 4579 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells transfected with human Mcl-1, untreated or treated with λ-phosphatase, using Phospho-Mcl-1 (Ser159/Thr163) Antibody (upper) or with total Mcl-1 Antibody #4572 (lower).

Mcl-1 (D35A5) Rabbit mAb - 5453 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D35A5
Western blot analysis of extracts from various cell lines using Mcl-1 (D35A5) Rabbit mAb.

Mcl-1 Antibody - 4572 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Raji, Ramos and BL41-3 (a subline of BL41 Burkitt lymphoma cells found to have amplified expression of Mcl-1) cells, using Mcl-1 Antibody.

Mcl-1 (S-19) - sc-819 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Mcl-1 (S-19): sc-819. Western blot analysis of Mcl-1 expression in BJAB (A) and Ramos (B) whole cell lysates.

Mcl-1 (C-2) - sc-377487 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mcl-1 (C-2): sc-377487. Western blot analysis of Mcl-1 expression in non-transfected: sc-117752 (A) and human Mcl-1 transfected: sc-176626 (B) 293T whole cell lysates.

Mcl-1 (H-260) - sc-20679 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Mcl-1 (H-260): sc-20679. Western blot analysis of Mcl-1 long and short expression in BJAB whole cell lysate.

Mcl-1 (8C6D4B1) - sc-53951 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mcl-1 (8C6D4B1): sc-53951. Western blot analysis of Mcl-1 expression in HeLa (A), BCBL-1 (B), Jurkat (C), and HL-60 (D) whole cell lysates.

Mcl-1 (22) - sc-12756 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mcl-1 (22): sc-12756. Western blot analysis of Mcl-1 expression in BJAB (A), Ramos (B), JAR (C), K-562 (D) and Jurkat (E) whole cell lysates.

Mcl-1 (RC13) - sc-56152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mcl-1 (RC13): sc-56152. Western blot analysis of Mcl-1 expression in BJAB (A), Ramos (B), JAR (C) and K-562 (D) whole cell lysates.

Mcl-1 (RC31) - sc-53971 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mcl-1 (RC31): sc-53971. Western blot analysis of Mcl-1 expression in BJAB (A), Ramos (B) and K-562 (C) whole cell lysates.

Mcl-1 (MCL701) - sc-69838 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mcl-1 (MCL701): sc-69838. Western blot analysis of Mcl-1 expression in Ramos whole cell lysate.

Mcl-1 (MCL-2601) - sc-69840 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mcl-1 (MCL-2601): sc-69840. Western blot analysis of Mcl-1 expression in Ramos whole cell lysate.

Mcl-1 (MCL-1801) - sc-69841 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Mcl-1 (MCL-401) - sc-69839 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mcl-1 (MCL-401): sc-69839. Western blot analysis of Mcl-1 expression in Ramos (A) and K-562 (B) whole cell lysates.

Mcl-1 (B-6) - sc-74436 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mcl-1 (B-6): sc-74436. Western blot analysis of Mcl-1 expression in Ramos (A), K-562 (B) and AML-193 (C) whole cell lysates.

Mcl-1 (G-7) - sc-74437 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mcl-1 (G-7): sc-74437. Western blot analysis of Mcl-1 expression in Ramos (A), K-562 (B) and AML-193 (C) whole cell lysates.

Mcl-1 (SPM343) - sc-56427 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mcl-1 (SPM343): sc-56427. Western blot analysis of Mcl-1 expression in non-transfected 293T: sc-117752 (A), mouse Mcl-1 transfected 293T: sc-121559 (B) and BJAB (C) whole cell lysates.

Mcl-1 L (K-20) - sc-958 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Mcl-1<sub>L</sub> (K-20): sc-958. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of decidual cells.

Anti-MCL1 (phospho S159) antibody - ab111574 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111574, at 1/100 dilution, staining MCL1 in A549 cells by Immunofluorescence, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-MCL1 antibody - ab53709 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MCL1 antibody (ab53709) at 1/500 dilutionLane 1 : Extracts from HuvEc cells minus the immunising peptideLane 2 : Extracts from HuvEc cells plus the immunising peptide

Anti-MCL1 antibody - ab25955 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab25955 at 2µg/ml staining MCL1 in Raji cells by ICC/IF

Anti-MCL1 antibody - ab28147 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of MCL1 staining in human lung formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab28147, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-MCL1 antibody - ab137350 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-MCL1 antibody (ab137350) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-MCL1 antibody - ab25956 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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