MCL1

Gene Symbol	MCL1
Entrez Gene	4170
Alt Symbol	BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
Species	Human
Gene Type	protein-coding
Description	myeloid cell leukemia 1
Other Description	bcl-2-like protein 3|bcl-2-related protein EAT/mcl1|induced myeloid leukemia cell differentiation protein Mcl-1|myeloid cell leukemia ES|myeloid cell leukemia sequence 1 (BCL2-related)
Swissprots	Q9UHR8 Q07820 Q9HD91 D3DV04 B2R6B2 Q9UNJ1 Q9NRQ4 D3DV03 Q9NRQ3 Q9UHR9 Q9UHR7
Accessions	AAF64255 AAF64256 AAF74821 AAG00896 AAY68220 EAW53538 EAW53539 EAW53540 EAW53541 Q07820 AA453505 AF118124 AAD13299 AF118276 AAF15309 AF118277 AAF15310 AF118278 AAF15311 AF203373 AAG00904 AK294462 BAG57694 AK297217 BAG59700 AK300499 BAG62213 AK304775 BAG65530 AK312508 BAG35409 AK316267 BAH14638 BC017197 AAH17197 BC071897 AAH71897 BC107735 AAI07736 BT006640 AAP35286 CA421486 DQ890628 ABM92245 DQ893795 ABM84721 FJ917536 ACV83304 L08246 NM_001197320 NP_001184249 NM_021960 NP_068779 NM_182763 NP_877495
Function	Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
Top Pathways	PI3K-Akt signaling pathway, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence® Mcl-1 siRNA I - 6315 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Mcl-1 CRISPR/Cas9 KO Plasmid (h) - sc-400079 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mcl-1 HDR Plasmid (h) - sc-400079-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mcl-1 Double Nickase Plasmid (h) - sc-400079-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mcl-1 Double Nickase Plasmid (h2) - sc-400079-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mcl-1 CRISPR Activation Plasmid (h) - sc-400079-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mcl-1 CRISPR Activation Plasmid (h2) - sc-400079-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mcl-1 Lentiviral Activation Particles (h) - sc-400079-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mcl-1 Lentiviral Activation Particles (h2) - sc-400079-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mcl-1 siRNA (h) - sc-35877 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mcl-1 shRNA Plasmid (h) - sc-35877-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mcl-1 shRNA (h) Lentiviral Particles - sc-35877-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mcl-1 L siRNA (h) - sc-43912 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mcl-1 L shRNA Plasmid (h) - sc-43912-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mcl-1 L shRNA (h) Lentiviral Particles - sc-43912-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mcl-1 RNAi - H00004170-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

Mcl-1 RNAi - H00004170-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU079921 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13115 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13115 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00010 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00010

MCL1 siRNA (Human) - CRH2838 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human MCL1 (NM_021960.4) - SHH339251 from Creative biogene Category siRNA Species Reactivities Human

Human MCL1 siRNA - orb263340 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MCL1 siRNA gene - orb219181 from Biorbyt Category siRNA Prices $417.00 Sizes 5 od (260 nm) Species Reactivities Human

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