| Gene Symbol |
GPC6
|
| Entrez Gene |
10082
|
| Alt Symbol |
OMIMD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glypican 6
|
| Other Description |
glypican proteoglycan 6|glypican-6
|
| Swissprots |
Q96SG5 A8K279 Q9H1P4 Q9Y625 Q96SG8
|
| Accessions |
EAX08931 EAX08932 EAX08933 EAX08934 Q9Y625 AF105267 AAD55749 AF111178 AAD31392 AK074741 AK130013 AK290144 BAF82833 AK304338 BAG65183 AY358462 AAQ88827 BC106947 AAI06948 BQ009005 BQ182216 BX640888 XM_011521044 XP_011519346 NM_005708 NP_005699
|
| Function |
Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling. {ECO:0000250, ECO:0000269|PubMed:21871017}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. Detected in breast cancer cells (at protein level). {ECO:0000269|PubMed:10480909, ECO:0000269|PubMed:21871017}.
|
![Western Blot: Glypican-6 Overexpression Lysate (Adult Normal) [NBL1-11223] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Glypican-6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14378_Glypican-6%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-11223-img0002.jpg)