| Gene Symbol |
CLEC9A
|
| Entrez Gene |
283420
|
| Alt Symbol |
DNGR1, UNQ9341
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
C-type lectin domain family 9, member A
|
| Other Description |
C-type lectin domain family 9 member A|HEEE9341
|
| Swissprots |
B0ZBM2 Q6UXN8
|
| Accessions |
Q6UXN8 AK307335 AY358265 AAQ88632 DB090462 DB526089 EU339276 ABZ04557 NM_207345 NP_997228
|
| Function |
Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. {ECO:0000269|PubMed:18497879, ECO:0000269|PubMed:22483802}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:18408006}; Single-pass type II membrane protein {ECO:0000269|PubMed:18408006}.
|
| Tissue Specificity |
In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes. {ECO:0000269|PubMed:18408006, ECO:0000269|PubMed:18497879}.
|