Gene Symbol | CLEC9A |
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Entrez Gene | 283420 |
Alt Symbol | DNGR1, UNQ9341 |
Species | Human |
Gene Type | protein-coding |
Description | C-type lectin domain family 9, member A |
Other Description | C-type lectin domain family 9 member A|HEEE9341 |
Swissprots | B0ZBM2 Q6UXN8 |
Accessions | Q6UXN8 AK307335 AY358265 AAQ88632 DB090462 DB526089 EU339276 ABZ04557 NM_207345 NP_997228 |
Function | Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. {ECO:0000269|PubMed:18497879, ECO:0000269|PubMed:22483802}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:18408006}; Single-pass type II membrane protein {ECO:0000269|PubMed:18408006}. |
Tissue Specificity | In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes. {ECO:0000269|PubMed:18408006, ECO:0000269|PubMed:18497879}. |
CLEC-9A CRISPR/Cas9 KO Plasmid (h) - sc-415313 from Santa Cruz Biotechnology
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CLEC-9A HDR Plasmid (h) - sc-415313-HDR from Santa Cruz Biotechnology
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CLEC-9A Double Nickase Plasmid (h) - sc-415313-NIC from Santa Cruz Biotechnology
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CLEC-9A Double Nickase Plasmid (h2) - sc-415313-NIC-2 from Santa Cruz Biotechnology
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CLEC-9A CRISPR Activation Plasmid (h) - sc-415313-ACT from Santa Cruz Biotechnology
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CLEC-9A CRISPR Activation Plasmid (h2) - sc-415313-ACT-2 from Santa Cruz Biotechnology
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CLEC-9A Lentiviral Activation Particles (h) - sc-415313-LAC from Santa Cruz Biotechnology
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CLEC-9A Lentiviral Activation Particles (h2) - sc-415313-LAC-2 from Santa Cruz Biotechnology
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CLEC-9A siRNA (h) - sc-95810 from Santa Cruz Biotechnology
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CLEC-9A shRNA Plasmid (h) - sc-95810-SH from Santa Cruz Biotechnology
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CLEC-9A shRNA (h) Lentiviral Particles - sc-95810-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN6225 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6225 from Sigma-Aldrich
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CLEC9A siRNA (Human) - CRJ6904 from Cohesion Biosciences
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CLEC9A - MBS8235651 from MyBioSource
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shRNA set against Human CLEC9A (NM_207345.2) - SHH265245 from Creative biogene
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Human CLEC9A siRNA - orb277405 from Biorbyt
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CLEC9A shRNA Plasmid (Human) - CHJ6904 from Cohesion Biosciences
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CLEC9A miRNA 3'UTR clone - MiUTR1H-02219 from Creative biogene
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