| Gene Symbol |
RHEBL1
|
| Entrez Gene |
121268
|
| Alt Symbol |
RHEBL1c
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras homolog enriched in brain like 1
|
| Other Description |
GTPase RhebL1|Ras homolog enriched in brain like 1 c|ras homolog enriched in brain like-1 c|ras homolog enriched in brain-like protein 1|rheb-like protein 1|rheb2
|
| Swissprots |
Q8TAI7 Q56VH8
|
| Accessions |
CCQ43838 EAW58037 EAW58038 Q8TAI7 AI917432 AK098663 BAC05370 AY327412 AAP92804 AY509932 AAS80166 BC014155 AAH14155 BC027482 AAH27482 NM_001303126 NP_001290055 NM_144593 NP_653194 NR_130123
|
| Function |
Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2. {ECO:0000269|PubMed:12869548, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:16328882, ECO:0000269|PubMed:17162089}.
|
| Subcellular Location |
Endomembrane system {ECO:0000305|PubMed:16328882}; Lipid-anchor {ECO:0000305|PubMed:16006564}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16328882}.
|
| Tissue Specificity |
Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines. {ECO:0000269|PubMed:16006564, ECO:0000269|PubMed:16328882}.
|
