Gene Symbol | RHEBL1 |
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Entrez Gene | 121268 |
Alt Symbol | RHEBL1c |
Species | Human |
Gene Type | protein-coding |
Description | Ras homolog enriched in brain like 1 |
Other Description | GTPase RhebL1|Ras homolog enriched in brain like 1 c|ras homolog enriched in brain like-1 c|ras homolog enriched in brain-like protein 1|rheb-like protein 1|rheb2 |
Swissprots | Q8TAI7 Q56VH8 |
Accessions | CCQ43838 EAW58037 EAW58038 Q8TAI7 AI917432 AK098663 BAC05370 AY327412 AAP92804 AY509932 AAS80166 BC014155 AAH14155 BC027482 AAH27482 NM_001303126 NP_001290055 NM_144593 NP_653194 NR_130123 |
Function | Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2. {ECO:0000269|PubMed:12869548, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:16328882, ECO:0000269|PubMed:17162089}. |
Subcellular Location | Endomembrane system {ECO:0000305|PubMed:16328882}; Lipid-anchor {ECO:0000305|PubMed:16006564}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16328882}. |
Tissue Specificity | Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines. {ECO:0000269|PubMed:16006564, ECO:0000269|PubMed:16328882}. |
RhebL1 CRISPR/Cas9 KO Plasmid (h) - sc-406987 from Santa Cruz Biotechnology
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RhebL1 HDR Plasmid (h) - sc-406987-HDR from Santa Cruz Biotechnology
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RhebL1 Double Nickase Plasmid (h) - sc-406987-NIC from Santa Cruz Biotechnology
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RhebL1 Double Nickase Plasmid (h2) - sc-406987-NIC-2 from Santa Cruz Biotechnology
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RhebL1 CRISPR Activation Plasmid (h) - sc-406987-ACT from Santa Cruz Biotechnology
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RhebL1 CRISPR Activation Plasmid (h2) - sc-406987-ACT-2 from Santa Cruz Biotechnology
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RhebL1 Lentiviral Activation Particles (h) - sc-406987-LAC from Santa Cruz Biotechnology
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RhebL1 Lentiviral Activation Particles (h2) - sc-406987-LAC-2 from Santa Cruz Biotechnology
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RhebL1 siRNA (h) - sc-95811 from Santa Cruz Biotechnology
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RhebL1 shRNA Plasmid (h) - sc-95811-SH from Santa Cruz Biotechnology
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RhebL1 shRNA (h) Lentiviral Particles - sc-95811-V from Santa Cruz Biotechnology
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RHEBL1 RNAi - H00121268-R01 from Novus Biologicals
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MISSION® esiRNA - EHU013591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18249 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18249 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03565 from Sigma-Aldrich
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RHEBL1 siRNA (Human) - CRJ4664 from Cohesion Biosciences
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RHEBL1 - MBS8220748 from MyBioSource
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shRNA set against Human RHEBL1 (NM_144593.1) - SHH395240 from Creative biogene
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shRNA set against Human RHEBL1(NM_144593.1) - SHR180564 from Creative biogene
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RHEBL1 shRNA Plasmid (Human) - CHJ4664 from Cohesion Biosciences
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RHEBL1 miRNA 3'UTR clone - MiUTR1H-08808 from Creative biogene
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