| Gene Symbol |
CATSPER2
|
| Entrez Gene |
117155
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cation channel, sperm associated 2
|
| Other Description |
cation channel sperm-associated protein 2|sperm ion channel
|
| Swissprots |
Q96P55 Q96P54 Q8NHT9 Q96P56
|
| Accessions |
EAW50798 EAW50801 EAW50802 Q96P56 AF411817 AAL26490 AF411818 AAL26491 AF411819 AAL26492 AK093318 AK122607 BAG53620 AW135409 BC028728 AAH28728 BC064387 AAH64387 BM998110 BX648099 DQ655952 HQ448354 ADQ32834 XM_011521204 XP_011519506 NM_001282309 NP_001269238 NM_001282310 NP_001269239 NM_054020 NP_473361 NM_172095 NP_742093 NR_110319 NM_172097
|
| Function |
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.
|
| Subcellular Location |
Cell projection, cilium, flagellum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Specifically located in the principal piece of sperm tail.
|
| Tissue Specificity |
Testis-specific. {ECO:0000269|PubMed:11675491, ECO:0000269|PubMed:17347248}.
|