Gene Symbol | CATSPER2 |
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Entrez Gene | 117155 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | cation channel, sperm associated 2 |
Other Description | cation channel sperm-associated protein 2|sperm ion channel |
Swissprots | Q96P55 Q96P54 Q8NHT9 Q96P56 |
Accessions | EAW50798 EAW50801 EAW50802 Q96P56 AF411817 AAL26490 AF411818 AAL26491 AF411819 AAL26492 AK093318 AK122607 BAG53620 AW135409 BC028728 AAH28728 BC064387 AAH64387 BM998110 BX648099 DQ655952 HQ448354 ADQ32834 XM_011521204 XP_011519506 NM_001282309 NP_001269238 NM_001282310 NP_001269239 NM_054020 NP_473361 NM_172095 NP_742093 NR_110319 NM_172097 |
Function | Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}. |
Subcellular Location | Cell projection, cilium, flagellum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Specifically located in the principal piece of sperm tail. |
Tissue Specificity | Testis-specific. {ECO:0000269|PubMed:11675491, ECO:0000269|PubMed:17347248}. |
CatSper2 (H-60) - sc-98539 from Santa Cruz Biotechnology
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CatSper2 (L-17) - sc-83119 from Santa Cruz Biotechnology
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CatSper2 (T-17) - sc-83122 from Santa Cruz Biotechnology
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Anti-CatSper2 antibody - ab150890 from Abcam
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Anti-CatSper2 antibody - ab49341 from Abcam
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Anti-CatSper2 antibody - ab66642 from Abcam
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Anti-CATSPER2 Antibody (aa31-80) - LS-C31616 from LifeSpan Bioscience
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Anti-CATSPER2 Antibody (aa472-500) - LS-C320017 from LifeSpan Bioscience
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Anti-CATSPER2 Antibody (C-Terminus) - LS-C31685 from LifeSpan Bioscience
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Anti-CATSPER2 Antibody (aa31-80) - LS-C115945 from LifeSpan Bioscience
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Anti-CATSPER2 Antibody (aa472-500) - LS-C159272 from LifeSpan Bioscience
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Anti-CATSPER2 Antibody (aa472-500, AP) - LS-C233397 from LifeSpan Bioscience
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Anti-CATSPER2 Antibody (aa472-500, Biotin) - LS-C233398 from LifeSpan Bioscience
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Anti-CATSPER2 Antibody (aa472-500, PE) - LS-C233404 from LifeSpan Bioscience
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Anti-CATSPER2 Antibody (aa472-500, Azide-free, HRP) - LS-C249578 from LifeSpan Bioscience
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Anti-CATSPER2 Antibody (aa472-500, APC) - LS-C233399 from LifeSpan Bioscience
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Anti-CATSPER2 Antibody (aa472-500, FITC) - LS-C233400 from LifeSpan Bioscience
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CatSper2 Antibody - NBP2-14439 from Novus Biologicals
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CatSper2 Antibody - NBP1-46506 from Novus Biologicals
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Rabbit Anti-CATSPER2 Polyclonal Antibody - bs-10473R from Bioss
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Rabbit Anti-CATSPER2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-10473R-A350 from Bioss
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Rabbit Anti-CATSPER2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-10473R-A488 from Bioss
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Rabbit Anti-CATSPER2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-10473R-A555 from Bioss
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Rabbit Anti-CATSPER2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-10473R-A647 from Bioss
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Rabbit Anti-CATSPER2 Polyclonal Antibody, Cy3 Conjugated - bs-10473R-Cy3 from Bioss
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