CATSPER2

Gene Symbol	CATSPER2
Entrez Gene	117155
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	cation channel, sperm associated 2
Other Description	cation channel sperm-associated protein 2|sperm ion channel
Swissprots	Q96P55 Q96P54 Q8NHT9 Q96P56
Accessions	EAW50798 EAW50801 EAW50802 Q96P56 AF411817 AAL26490 AF411818 AAL26491 AF411819 AAL26492 AK093318 AK122607 BAG53620 AW135409 BC028728 AAH28728 BC064387 AAH64387 BM998110 BX648099 DQ655952 HQ448354 ADQ32834 XM_011521204 XP_011519506 NM_001282309 NP_001269238 NM_001282310 NP_001269239 NM_054020 NP_473361 NM_172095 NP_742093 NR_110319 NM_172097
Function	Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.
Subcellular Location	Cell projection, cilium, flagellum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Specifically located in the principal piece of sperm tail.
Tissue Specificity	Testis-specific. {ECO:0000269|PubMed:11675491, ECO:0000269|PubMed:17347248}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CATSPER2 Antibody Blocking Peptide - LS-E6309 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CATSPER2 Antibody Blocking Peptide - LS-E12605 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CATSPER2 Antibody Blocking Peptide - LS-E12607 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CATSPER2 Antibody Blocking Peptide - LS-E12606 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CATSPER2-Antibody-C-term-Blocking-Peptide - BP18998b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CATSPER2 Blocking Peptide - 33R-5202 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CATSPER2 Blocking Peptide - 33R-3784 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CATSPER2 Blocking Peptide - 33R-3783 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CatSper2 Protein - NBP2-14439PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

CATSPER2 Peptide, Human - M34GP02410H from Creative Peptides Category Peptide Source Synthetic. Species Human

Cation channel sperm-associated protein 2 (CATSPER2), Recombinant Protein - MBS7010768 from MyBioSource Category Protein Prices $1,330.00, $2,315.00, $3,520.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

CATSPER2 fusion protein - Ag26069 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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