CATSPER2
| Gene Symbol | CATSPER2 |
|---|---|
| Entrez Gene | 117155 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | cation channel, sperm associated 2 |
| Other Description | cation channel sperm-associated protein 2|sperm ion channel |
| Swissprots | Q96P55 Q96P54 Q8NHT9 Q96P56 |
| Accessions | EAW50798 EAW50801 EAW50802 Q96P56 AF411817 AAL26490 AF411818 AAL26491 AF411819 AAL26492 AK093318 AK122607 BAG53620 AW135409 BC028728 AAH28728 BC064387 AAH64387 BM998110 BX648099 DQ655952 HQ448354 ADQ32834 XM_011521204 XP_011519506 NM_001282309 NP_001269238 NM_001282310 NP_001269239 NM_054020 NP_473361 NM_172095 NP_742093 NR_110319 NM_172097 |
| Function | Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}. |
| Subcellular Location | Cell projection, cilium, flagellum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Specifically located in the principal piece of sperm tail. |
| Tissue Specificity | Testis-specific. {ECO:0000269|PubMed:11675491, ECO:0000269|PubMed:17347248}. |
CatSper2 CRISPR/Cas9 KO Plasmid (h) - sc-410266 from Santa Cruz Biotechnology
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CatSper2 HDR Plasmid (h) - sc-410266-HDR from Santa Cruz Biotechnology
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CatSper2 Double Nickase Plasmid (h) - sc-410266-NIC from Santa Cruz Biotechnology
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CatSper2 Double Nickase Plasmid (h2) - sc-410266-NIC-2 from Santa Cruz Biotechnology
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CatSper2 CRISPR Activation Plasmid (h) - sc-410266-ACT from Santa Cruz Biotechnology
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CatSper2 CRISPR Activation Plasmid (h2) - sc-410266-ACT-2 from Santa Cruz Biotechnology
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CatSper2 Lentiviral Activation Particles (h) - sc-410266-LAC from Santa Cruz Biotechnology
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CatSper2 Lentiviral Activation Particles (h2) - sc-410266-LAC-2 from Santa Cruz Biotechnology
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CatSper2 siRNA (h) - sc-72809 from Santa Cruz Biotechnology
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CatSper2 shRNA Plasmid (h) - sc-72809-SH from Santa Cruz Biotechnology
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CatSper2 shRNA (h) Lentiviral Particles - sc-72809-V from Santa Cruz Biotechnology
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CatSper2 RNAi - H00117155-R04 from Novus Biologicals
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CatSper2 RNAi - H00117155-R03 from Novus Biologicals
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MISSION® esiRNA - EHU088321 from Sigma-Aldrich
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MISSION® esiRNA - EHU103861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5396 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5396 from Sigma-Aldrich
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CATSPER2 siRNA (Human) - CRJ4552 from Cohesion Biosciences
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CatSper2 RNAi - H00117155-R02 from Novus Biologicals
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CatSper2 RNAi - H00117155-R01 from Novus Biologicals
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CATSPER2 - MBS8237976 from MyBioSource
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shRNA set against Human CATSPER2 (NM_054020.2) - SHH255149 from Creative biogene
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shRNA set against Human CATSPER2(NM_172095.1) - SHG143713 from Creative biogene
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shRNA set against Human CATSPER2(NM_054020.2) - SHG143773 from Creative biogene
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shRNA set against Human CATSPER2(NM_172097.1) - SHG143827 from Creative biogene
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