| Gene Symbol |
ARL3
|
| Entrez Gene |
403
|
| Alt Symbol |
ARFL3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ADP-ribosylation factor-like 3
|
| Other Description |
ADP-ribosylation factor-like protein 3|ARF-like 3
|
| Swissprots |
Q53X83 Q5JSM2 P36405 B2R6C7
|
| Accessions |
EAW49678 P36405 AA325516 AF038193 AF493889 AAM12603 AK312525 BAG35424 AW269939 BC008032 BC009841 AAH09841 BC025759 BE780186 BM661686 BQ638232 CD245572 CR407637 CAG28565 DQ893231 ABM84157 DQ896560 ABM87559 U07151 AAA21654 NM_004311 NP_004302
|
| Function |
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit. {ECO:0000269|PubMed:16525022, ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:22085962}.
|
| Subcellular Location |
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium. Note=Detected predominantly in the photoreceptor connecting cilium. Present on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules.
|
| Tissue Specificity |
Expressed in the retina. Strongly expressed in connecting cilium, the myoid region of the inner segments (IS) and in cone photoreceptors (at protein level). {ECO:0000269|PubMed:12417528}.
|
