ARL3

Gene Symbol ARL3
Entrez Gene 403
Alt Symbol ARFL3
Species Human
Gene Type protein-coding
Description ADP-ribosylation factor-like 3
Other Description ADP-ribosylation factor-like protein 3|ARF-like 3
Swissprots Q53X83 Q5JSM2 P36405 B2R6C7
Accessions EAW49678 P36405 AA325516 AF038193 AF493889 AAM12603 AK312525 BAG35424 AW269939 BC008032 BC009841 AAH09841 BC025759 BE780186 BM661686 BQ638232 CD245572 CR407637 CAG28565 DQ893231 ABM84157 DQ896560 ABM87559 U07151 AAA21654 NM_004311 NP_004302
Function Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit. {ECO:0000269|PubMed:16525022, ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:22085962}.
Subcellular Location Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium. Note=Detected predominantly in the photoreceptor connecting cilium. Present on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules.
Tissue Specificity Expressed in the retina. Strongly expressed in connecting cilium, the myoid region of the inner segments (IS) and in cone photoreceptors (at protein level). {ECO:0000269|PubMed:12417528}.

ARL3 CRISPR/Cas9 KO Plasmid (h) - sc-416856 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARL3 HDR Plasmid (h) - sc-416856-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARL3 Double Nickase Plasmid (h) - sc-416856-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARL3 Double Nickase Plasmid (h2) - sc-416856-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARL3 CRISPR Activation Plasmid (h) - sc-416856-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARL3 CRISPR Activation Plasmid (h2) - sc-416856-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARL3 Lentiviral Activation Particles (h) - sc-416856-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARL3 Lentiviral Activation Particles (h2) - sc-416856-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARL3 siRNA (h) - sc-61990 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ARL3 shRNA Plasmid (h) - sc-61990-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ARL3 shRNA (h) Lentiviral Particles - sc-61990-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU003741 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3489 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3489 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ARL3 siRNA (Human) - CRH0292 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ARL3 - MBS8210035 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ARL3 (NM_004311.3) - SHH240194 from Creative biogene

Category siRNA
Species Reactivities Human

ARL3 shRNA Plasmid (Human) - CHH0292 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ARL3 miRNA 3'UTR clone - MiUTR4H-TG00497 from Creative biogene

Species Reactivities Human
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