| Gene Symbol | LSM6 |
|---|---|
| Entrez Gene | 11157 |
| Alt Symbol | YDR378C |
| Species | Human |
| Gene Type | protein-coding |
| Description | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| Other Description | Sm protein F|U6 snRNA-associated Sm-like protein LSm6 |
| Swissprots | P62312 Q4W5J5 |
| Accessions | AAY41032 EAX05029 EAX05030 EAX05031 P62312 AF182292 AAD56230 AI351504 AJ238098 CAB45869 AK312126 BAG35062 BC016026 AAH16026 BC019894 DB465201 DQ892328 ABM83254 EU176507 ABW03308 NM_007080 NP_009011 |
| Function | Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12515382}. Nucleus {ECO:0000250}. |
| Top Pathways | RNA degradation, Spliceosome |