LSM6

Gene Symbol	LSM6
Entrez Gene	11157
Alt Symbol	YDR378C
Species	Human
Gene Type	protein-coding
Description	LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Other Description	Sm protein F|U6 snRNA-associated Sm-like protein LSm6
Swissprots	P62312 Q4W5J5
Accessions	AAY41032 EAX05029 EAX05030 EAX05031 P62312 AF182292 AAD56230 AI351504 AJ238098 CAB45869 AK312126 BAG35062 BC016026 AAH16026 BC019894 DB465201 DQ892328 ABM83254 EU176507 ABW03308 NM_007080 NP_009011
Function	Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12515382}. Nucleus {ECO:0000250}.
Top Pathways	RNA degradation, Spliceosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LSM6 protein (His tag) - ab127443 from Abcam Category Protein Source E. coli Species Human

LSM6 Antibody Blocking Peptide - LS-E14913 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LSM6 Antibody Blocking Peptide - LS-E14912 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LSM6 Antibody Blocking Peptide - LS-E27917 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LSM6 Protein - H00011157-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LSM6 Blocking Peptide - 33R-10223 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LSM6 Blocking Peptide - 33R-6468 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LSM6 Peptide - AC21-2690-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

LSM6 - H00011157-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LSM6 - H00011157-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

LSM6 Peptide - 43-060P from ProSci Category Peptide

LSM6 fusion protein - ag8292 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

LSM6 fusion protein - Ag2784 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human U6 snRNA-associated Sm-like protein LSm6(LSM6) - CSB-YP013209HU CSB-EP013209HU CSB-BP013209HU CSB-MP013209HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

LSM6 - TP302373 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

LSM6, Peptide - MBS427925 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

LSM6 Recombinant Protein Antigen - NBP1-92083PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

LSM6 Peptide, Human - M34GP08969H from Creative Peptides Category Peptide Source Synthetic. Species Human

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