LSM6

Gene Symbol LSM6
Entrez Gene 11157
Alt Symbol YDR378C
Species Human
Gene Type protein-coding
Description LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Other Description Sm protein F|U6 snRNA-associated Sm-like protein LSm6
Swissprots P62312 Q4W5J5
Accessions AAY41032 EAX05029 EAX05030 EAX05031 P62312 AF182292 AAD56230 AI351504 AJ238098 CAB45869 AK312126 BAG35062 BC016026 AAH16026 BC019894 DB465201 DQ892328 ABM83254 EU176507 ABW03308 NM_007080 NP_009011
Function Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12515382}. Nucleus {ECO:0000250}.
Top Pathways RNA degradation, Spliceosome

LSm6 CRISPR/Cas9 KO Plasmid (h) - sc-416944 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LSm6 HDR Plasmid (h) - sc-416944-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LSm6 Double Nickase Plasmid (h) - sc-416944-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LSm6 Double Nickase Plasmid (h2) - sc-416944-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LSm6 CRISPR Activation Plasmid (h) - sc-416944-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LSm6 CRISPR Activation Plasmid (h2) - sc-416944-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LSm6 Lentiviral Activation Particles (h) - sc-416944-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LSm6 Lentiviral Activation Particles (h2) - sc-416944-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LSm6 siRNA (h) - sc-75711 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LSm6 shRNA Plasmid (h) - sc-75711-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LSm6 shRNA (h) Lentiviral Particles - sc-75711-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU009461 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12802 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12802 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LSM6 siRNA (Human) - CRH7638 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LSM6 RNAi - H00011157-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human LSM6 (NM_007080.2) - SHH335311 from Creative biogene

Category siRNA
Species Reactivities Human

LSM6 shRNA Plasmid (Human) - CHH7638 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LSM6 miRNA 3'UTR clone - MiUTR1H-05943 from Creative biogene

Species Reactivities Human
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