TLR9

Gene Symbol	TLR9
Entrez Gene	54106
Alt Symbol	CD289
Species	Human
Gene Type	protein-coding
Description	toll-like receptor 9
Other Description	-
Swissprots	Q9HD70 Q9NYC3 B3Y661 Q9NYC2 D1CS56 Q9HD69 Q6UVZ2 Q9NR96 Q9HD68
Accessions	AAZ95513 AAZ95514 AAZ95515 AAZ95516 AAZ95517 AAZ95518 AAZ95519 AAZ95520 ABW37074 ABW37075 ABW37076 ABW37077 ABW37078 ACQ41818 ACQ41819 ACQ41820 ACQ41821 ACQ41822 ACQ41823 ACQ41824 ACQ41825 ACQ41826 ACQ41827 ACQ41828 ACQ41829 ACQ41830 ACQ41831 CCQ43550 EAW65191 EAW65193 Q9NR96 AB045180 BAB19259 AB445673 BAG55070 AF245704 AAF78037 AF246972 AAG01734 AF259262 AAF72189 AF259263 AAF72190 AY359085 AAQ89443 BC032713 AAH32713 EU831821 ACE87339 EU831898 ACE86657 NM_017442 NP_059138 NM_138688
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. {ECO:0000269|PubMed:11564765, ECO:0000269|PubMed:17932028}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250}.
Tissue Specificity	Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
Top Pathways	Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Malaria, African trypanosomiasis, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TLR9 peptide - ab40022 from Abcam Category Peptide Species Human

Human TLR9 protein fragment - ab153365 from Abcam Category Protein Source Wheat germ Species Human

TLR9 peptide - ab197409 from Abcam Category Peptide

TLR9 Antibody Blocking Peptide - LS-E2647 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TLR9 Antibody Blocking Peptide - LS-E30210 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TLR9 Antibody Blocking Peptide - LS-E30211 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TLR9 Antibody Blocking Peptide - LS-E11723 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TLR9 Protein - H00054106-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TLR9 Blocking Peptide - NBP1-76680PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TLR9 Blocking Peptide - NBP1-77254PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TLR9 Recombinant Protein - H00054106-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

TLR9-Antibody-C-term-Blocking-peptide - BP13721b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TLR9 Blocking Peptide - 33R-9556 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TLR9 Blocking Peptide - 33R-10803 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

CD289 / TLR9 - H00054106-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD289 / TLR9 Control Peptide - AP10347CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

CD289 / TLR9 Control Peptide - AP30907CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

CD289 / TLR9 Control Peptide - AP30908CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TLR9 Peptide - 3737P from ProSci Category Peptide Species Human

TLR9 Peptide - 3739P from ProSci Category Peptide Species Human

TLR9 fusion protein - ag11071 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TLR9 fusion protein - Ag11122 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Toll Like Receptor 9 (TLR9) - RPA709Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Toll Like Receptor 9 (TLR9) - RPA709Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Toll Like Receptor 9 (TLR9) - RPA709Hu01 from Cloud-clone Category Protein Source E.coli Species Human

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