TLR9

Gene Symbol TLR9
Entrez Gene 54106
Alt Symbol CD289
Species Human
Gene Type protein-coding
Description toll-like receptor 9
Other Description -
Swissprots Q9HD70 Q9NYC3 B3Y661 Q9NYC2 D1CS56 Q9HD69 Q6UVZ2 Q9NR96 Q9HD68
Accessions AAZ95513 AAZ95514 AAZ95515 AAZ95516 AAZ95517 AAZ95518 AAZ95519 AAZ95520 ABW37074 ABW37075 ABW37076 ABW37077 ABW37078 ACQ41818 ACQ41819 ACQ41820 ACQ41821 ACQ41822 ACQ41823 ACQ41824 ACQ41825 ACQ41826 ACQ41827 ACQ41828 ACQ41829 ACQ41830 ACQ41831 CCQ43550 EAW65191 EAW65193 Q9NR96 AB045180 BAB19259 AB445673 BAG55070 AF245704 AAF78037 AF246972 AAG01734 AF259262 AAF72189 AF259263 AAF72190 AY359085 AAQ89443 BC032713 AAH32713 EU831821 ACE87339 EU831898 ACE86657 NM_017442 NP_059138 NM_138688
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. {ECO:0000269|PubMed:11564765, ECO:0000269|PubMed:17932028}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250}.
Tissue Specificity Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
Top Pathways Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Malaria, African trypanosomiasis, Measles

Toll-like Receptor 9 (D9M9H) XP ® Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 14279 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D9M9H
Flow cytometric analysis of human PBMCs using Toll-like Receptor 9 (D9M9H) XP ® Rabbit mAb (Alexa Fluor ® 647 Conjugate) co-stained with anti-CD11c (dendritic cell) and anti-CD3 (T cell) antibodies. Toll-like receptor 9 is clearly expressed on the CD11c+ dendritic cell population (left) and absent on the CD3+ T cells (right). The standard flow cytometry protocol was carried out using 50% methanol permeabilization (instead of 90%) to preserve cell surface epitopes.

Toll-like Receptor 9 (D9M9H) XP ® Rabbit mAb (PE Conjugate) - 14575 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D9M9H
Flow cytometric analysis of human whole blood using Toll-like Receptor 9 (D9M9H) XP ® Rabbit mAb (PE Conjugate) co-stained with either CD11c or CD3. CD11c+ dendritic cells are distinctly positive for toll-like receptor 9 while CD3+ T cells are negative.

Toll-like Receptor 9 (D9M9H) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 14252 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D9M9H
Flow cytometric analysis of lysed human whole blood using Toll-like Receptor 9 (D9M9H) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate) co-stained with anti-CD11c (dendritic cell) and anti-CD3 (T cell) antibodies. Toll-like receptor 9 is clearly expressed on the CD11c + dendritic cell population (left) while absent in the CD3+ T cells (right).

Toll-like Receptor 9 (D9M9H) XP ® Rabbit mAb - 13674 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9M9H
Western blot analysis of extracts from various cell lines using Toll-like Receptor 9 (D9M9H) XP ® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Toll-like Receptor 9 Antibody - 2254 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Raji and Ramos cells using Toll-like Receptor 9 Antibody.

Toll-like Receptor 9 (D2C9) Rabbit mAb - 5845 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2C9
Western blot analysis of extracts from various cell lines using Toll-like Receptor 9 (D2C9) Rabbit mAb.

TLR9 (C-20) - sc-13218 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLR9 (C-20): sc-13218. Western blot analysis of TLR9 expression in non-transfected 293T: sc-117752 (A), human TLR9 transfected 293T: sc-115275 (B) and HeLa (C) whole cell lysates.

TLR9 (D-18) - sc-16247 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TLR9 (H-100) - sc-25468 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TLR9 (N-15) - sc-13215 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TLR9 (26C593) - sc-52966 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TLR9 (26C593): sc-52966. Western blot analysis of TLR9 expression in non-transfected 293T: sc-117752 (A), human TLR9 transfected 293T: sc-115275 (B) and HeLa (C) whole cell lysates.

TLR9 (5G5) - sc-47723 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TLR9 (5G5): sc-47723. Western blot analysis of TLR9 expression in RAW 309 Cr.1 whole cell lysate.

Anti-TLR9 antibody - ab37154 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab37154 at 2 µg/ml staining TLR9 in mouse spleen cells by IHC.

Anti-TLR9 antibody - ab62577 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62577 at 2µg/ml staining TLR9 in Jurkat cells by Immunocytochemistry.

Anti-TLR9 antibody - ab52967 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TLR9 antibody (ab52967) at 0.5 µg/mlLane 2 : Anti-TLR9 antibody (ab52967) at 1 µg/mlLane 3 : Anti-TLR9 antibody (ab52967) at 2 µg/mlLane 1 : Jurkat cell lysateLane 2 : Jurkat cell lysateLane 3 : Jurkat cell lysateLysates/proteins at 15 µg per lane.

Anti-TLR9 antibody - ab88101 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-TLR9 antibody (ab88101) at 1 µg/ml + IMR-32 cell lysate at 50 µg

Anti-TLR9 antibody - ab125139 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab125139 at 5µg/ml staining TLR9 in formalin-fixed, paraffin-embedded Human liver tissue by Immunohistochemistry.

Anti-TLR9 antibody [26C593] - ab12121 from Abcam

Prices $394.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 26C593

Anti-TLR9 antibody [26C593.2] - ab134368 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 26C593.2
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Human spleen tissue labelling TLR9 with ab134368 at 5µg/ml. Staining was enhanced by boiling tissue sections in 10mM sodium citrate buffer, pH6.0 for 10-20 minutes followed by cooling at room temperature for 20 minutes.

Anti-TLR9 antibody [26C593.2] (FITC) - ab134369 from Abcam

Prices $160.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 26C593.2
Intracellular flow analysis of TLR9 in Human PBMCs (lymphocyte-gate), using 0.5 µg of ab134369 (red), cells without antibody (blue) and mouse IgG1-FITC isotype control (green).

Anti-TLR9 antibody [5G5] (FITC) - ab58864 from Abcam

Prices $190.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 5G5
THP1 cells were incubated with an IgG2a isotype control (A) or α-TLR9 5G5 mAb (B). Cells (140000) were permeabilized with saponin and stained with 0.4 µg 5G5.

Anti-TLR9 antibody [72-1665] - ab151221 from Abcam

Prices $384.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone 72-1665
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue labeling TLR9 with ab151221 at 20 µg/ml.

Anti-TLR9 antibody [EPR14964] - ab184943 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR14964
All lanes : Anti-TLR9 antibody [EPR14964] (ab184943) at 1/5000 dilutionLane 1 : Ramos cell lysateLane 2 : Raji cell lysateLysates/proteins at 20 µg per lane.Secondarygoat anti-rabbit IgG, (H+L), peroxidase conjugated at 1/1000 dilutiondeveloped using the ECL technique

Anti-TLR9 antibody [EPR14964-2] - ab187148 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14964-2
All lanes : Anti-TLR9 antibody [EPR14964-2] (ab187148) at 1/5000 dilutionLane 1 : Daudi cell lysateLane 2 : Raji cell lysateLane 3 : Ramos cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-TLR9 antibody - Aminoterminal end - ab53396 from Abcam

Prices $385.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
IH on paraffin section of human spleen using ab53396 at a concentration of 1/250.
Search more