| Gene Symbol |
BCAR3
|
| Entrez Gene |
8412
|
| Alt Symbol |
NSP2, SH2D3B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
breast cancer anti-estrogen resistance 3
|
| Other Description |
SH2 domain-containing protein 3B|breast cancer anti-estrogen resistance protein 3|breast cancer antiestrogen resistance 3 protein|dJ1033H22.2 (breast cancer anti-estrogen resistance 3)|novel SH2-containing protein 2
|
| Swissprots |
Q5TEW3 O75815 Q9BR50 D3DT43 Q6UW40
|
| Accessions |
EAW73065 EAW73066 EAW73067 EAW73068 O75815 AF124250 AAD28245 AK027785 BAG51378 AK055442 BAG51518 AK301570 BAG63064 AK310970 AL833121 AW470748 AY358996 AAQ89355 BC028477 BC039895 AAH39895 BQ015705 CN337133 DA057195 DA745974 EU832792 ACE87803 GQ129322 ACT64456 U92715 AAC39777 XM_011542251 XP_011540553 XM_011542252 XP_011540554 NM_001261408 NP_001248337 NM_001261409 NP_001248338 NM_001261410 NP_001248339 NM_001308251 NP_001295180 NM_003567 NP_003558
|
| Function |
May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. {ECO:0000269|PubMed:9582273}.
|
| Tissue Specificity |
Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue. {ECO:0000269|PubMed:10187783, ECO:0000269|PubMed:9582273}.
|
![Western Blot: BCAR3 Overexpression Lysate (Adult Normal) [NBL1-07936] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BCAR3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3281_BCAR3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07936-img0002.jpg)