Gene Symbol | BCAR3 |
---|---|
Entrez Gene | 8412 |
Alt Symbol | NSP2, SH2D3B |
Species | Human |
Gene Type | protein-coding |
Description | breast cancer anti-estrogen resistance 3 |
Other Description | SH2 domain-containing protein 3B|breast cancer anti-estrogen resistance protein 3|breast cancer antiestrogen resistance 3 protein|dJ1033H22.2 (breast cancer anti-estrogen resistance 3)|novel SH2-containing protein 2 |
Swissprots | Q5TEW3 O75815 Q9BR50 D3DT43 Q6UW40 |
Accessions | EAW73065 EAW73066 EAW73067 EAW73068 O75815 AF124250 AAD28245 AK027785 BAG51378 AK055442 BAG51518 AK301570 BAG63064 AK310970 AL833121 AW470748 AY358996 AAQ89355 BC028477 BC039895 AAH39895 BQ015705 CN337133 DA057195 DA745974 EU832792 ACE87803 GQ129322 ACT64456 U92715 AAC39777 XM_011542251 XP_011540553 XM_011542252 XP_011540554 NM_001261408 NP_001248337 NM_001261409 NP_001248338 NM_001261410 NP_001248339 NM_001308251 NP_001295180 NM_003567 NP_003558 |
Function | May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. {ECO:0000269|PubMed:9582273}. |
Tissue Specificity | Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue. {ECO:0000269|PubMed:10187783, ECO:0000269|PubMed:9582273}. |
BCAR3 CRISPR/Cas9 KO Plasmid (h) - sc-404301 from Santa Cruz Biotechnology
|
||||||||
BCAR3 HDR Plasmid (h) - sc-404301-HDR from Santa Cruz Biotechnology
|
||||||||
BCAR3 Double Nickase Plasmid (h) - sc-404301-NIC from Santa Cruz Biotechnology
|
||||||||
BCAR3 Double Nickase Plasmid (h2) - sc-404301-NIC-2 from Santa Cruz Biotechnology
|
||||||||
BCAR3 CRISPR Activation Plasmid (h) - sc-404301-ACT from Santa Cruz Biotechnology
|
||||||||
BCAR3 CRISPR Activation Plasmid (h2) - sc-404301-ACT-2 from Santa Cruz Biotechnology
|
||||||||
BCAR3 Lentiviral Activation Particles (h) - sc-404301-LAC from Santa Cruz Biotechnology
|
||||||||
BCAR3 Lentiviral Activation Particles (h2) - sc-404301-LAC-2 from Santa Cruz Biotechnology
|
||||||||
BCAR3 siRNA (h) - sc-60265 from Santa Cruz Biotechnology
|
||||||||
BCAR3 shRNA Plasmid (h) - sc-60265-SH from Santa Cruz Biotechnology
|
||||||||
BCAR3 shRNA (h) Lentiviral Particles - sc-60265-V from Santa Cruz Biotechnology
|
||||||||
BCAR3 RNAi - H00008412-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU060381 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN3891 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3891 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR04325 from Sigma-Aldrich
|
||||||||
BCAR3 siRNA (Human) - CRH5514 from Cohesion Biosciences
|
||||||||
BCAR3 - MBS8206923 from MyBioSource
|
||||||||
shRNA set against Human BCAR3 (NM_003567.3) - SHH245694 from Creative biogene
|
||||||||
Human BCAR3 siRNA - orb266016 from Biorbyt
|
||||||||
BCAR3 shRNA Plasmid (Human) - CHH5514 from Cohesion Biosciences
|
||||||||
BCAR3 miRNA 3'UTR clone - MiUTR3H-07024 from Creative biogene
|