Gene Symbol | BCAR3 |
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Entrez Gene | 8412 |
Alt Symbol | NSP2, SH2D3B |
Species | Human |
Gene Type | protein-coding |
Description | breast cancer anti-estrogen resistance 3 |
Other Description | SH2 domain-containing protein 3B|breast cancer anti-estrogen resistance protein 3|breast cancer antiestrogen resistance 3 protein|dJ1033H22.2 (breast cancer anti-estrogen resistance 3)|novel SH2-containing protein 2 |
Swissprots | Q5TEW3 O75815 Q9BR50 D3DT43 Q6UW40 |
Accessions | EAW73065 EAW73066 EAW73067 EAW73068 O75815 AF124250 AAD28245 AK027785 BAG51378 AK055442 BAG51518 AK301570 BAG63064 AK310970 AL833121 AW470748 AY358996 AAQ89355 BC028477 BC039895 AAH39895 BQ015705 CN337133 DA057195 DA745974 EU832792 ACE87803 GQ129322 ACT64456 U92715 AAC39777 XM_011542251 XP_011540553 XM_011542252 XP_011540554 NM_001261408 NP_001248337 NM_001261409 NP_001248338 NM_001261410 NP_001248339 NM_001308251 NP_001295180 NM_003567 NP_003558 |
Function | May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. {ECO:0000269|PubMed:9582273}. |
Tissue Specificity | Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue. {ECO:0000269|PubMed:10187783, ECO:0000269|PubMed:9582273}. |
Human BCAR3 peptide - ab45439 from Abcam
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Human BCAR3 protein fragment - ab160021 from Abcam
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BCAR3 Antibody Blocking Peptide - LS-E25219 from LifeSpan Bioscience
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BCAR3 Antibody Blocking Peptide - LS-E31318 from LifeSpan Bioscience
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BCAR3 Partial Recombinant Protein - H00008412-Q01 from Novus Biologicals
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BCAR3 blocking peptide - GTX89796-PEP from GeneTex
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BCAR3 Peptide - AC21-0041-P from Abcore
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BCAR3 / SH2D3B - H00008412-Q01-10 from Acris Antibodies
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BCAR3 / SH2D3B - H00008412-Q01-25 from Acris Antibodies
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BCAR3 / SH2D3B (N-term) Control Peptide - AP55492CP-N from Acris Antibodies
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BCAR3 Peptide - 6999P from ProSci
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BCAR3 Peptide - 45-324P from ProSci
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BCAR3 fusion protein - Ag24621 from Proteintech Group
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BCAR3 fusion protein - Ag4546 from Proteintech Group
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BCAR3 fusion protein - Ag5300 from Proteintech Group
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Recombinant Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) - RPG768Hu01 from Uscn Life Science Inc.
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Recombinant Human Breast cancer anti-estrogen resistance protein 3(BCAR3) ,partial - CSB-YP002594HU CSB-EP002594HU CSB-BP002594HU CSB-MP002594HU from Cusabio
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BCAR3 / SH2D3B - TP307930 from Acris Antibodies
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BCAR3, Peptide - MBS425862 from MyBioSource
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BCAR3 Recombinant Protein Antigen - NBP1-82523PEP from Novus Biologicals
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BCAR3 Blocking Peptide - abx061675 from Abbexa
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BCAR3 Peptide, Human - M34GP01354H from Creative Peptides
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BCAR3 Blocking Peptide - CBP7065 from Cohesion Biosciences
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BCAR3 Immunizing peptide - orb17341 from Biorbyt
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BCAR3 Recombinant Protein (OPCD01592) - OPCD01592 from Aviva Systems Biology
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