Nkx2-2

Gene Symbol	Nkx2-2
Entrez Gene	18088
Alt Symbol	Nkx-2.2, Nkx2.2, tinman
Species	Mouse
Gene Type	protein-coding
Description	NK2 homeobox 2
Other Description	Drosophila NK2 transcription factor related, locus 2\|NK2 transcription factor related, locus 2\|glycoprotein GP330, renal\|homeobox protein NK-2 homolog B\|homeobox protein Nkx-2.2\|homeobox protein Nkx2-2
Swissprots	P42586
Accessions	AAF44652 P42586 AK043561 BAC31582 AK141002 BAE24543 AK162904 BAE37107 BB183898 BC138159 AAI38160 BC138160 AAI38161 U31566 AAA79303 XM_006498898 XP_006498961 XM_006498899 XP_006498962 XM_006498900 XP_006498963 XM_011239349 XP_011237651 NM_001077632 NP_001071100 NM_010919 NP_035049
Function	Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. {ECO:0000269\|PubMed:19759004}.
Subcellular Location	Nucleus {ECO:0000255\|PROSITE- ProRule:PRU00108, ECO:0000269\|PubMed:14573534}.
Tissue Specificity	Expressed in restricted areas of the developing CNS: the hindbrain and forebrain, and pancreas.
Top Pathways	Maturity onset diabetes of the young

Nkx-2.2 (L-25) - sc-133825 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Rabbit
Clonality	Polyclonal

Nkx-2.2 (L-25): sc-133825. Western blot analysis of Nkx-2.2 expression in SP2/0 whole cell lysate.

Anti-Nkx2.2 antibody - ab93188 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Nkx2.2 antibody (ab93188) at 1 µg/mlLane 1 : Spinal Cord (Mouse) Tissue LysateLane 2 : Brain (Mouse) Tissue Lysate Lane 3 : Cerebellum Mouse Tissue LysateLane 4 : Mouse Hippocampus Tissue LysateLane 5 : Mouse Hippocampus Tissue Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-NKX2-2 Antibody (aa91-120, AP) - LS-C238053 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NKX2-2 Antibody (clone NX2/294) - LS-C191688 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	NX2/294

Immunohistochemistry of formalin-fixed, paraffin-embedded human pancreas stained with NKX2.2 NX2/294 antibody (1:100), peroxidase-conjugate and DAB chromogen.

Anti-NKX2-2 Antibody (aa30-79) - LS-C30113 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NKX2-2 Antibody (aa91-120, APC) - LS-C238054 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NKX2-2 Antibody (aa91-120, Biotin) - LS-C238055 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NKX2-2 Antibody (aa91-120, FITC) - LS-C238056 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NKX2-2 Antibody (aa91-120, PE) - LS-C238057 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NKX2-2 Antibody (aa91-120, Azide-free, HRP) - LS-C248921 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NKX2-2 Antibody (aa98-128) - LS-C323354 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NKX2-2 Antibody (N-Terminus) - LS-C109653 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

NKX2-2 antibody LS-C109653 Western blot of Fetal Spleen lysate.

Anti-NKX2-2 Antibody (N-Terminus) - LS-C101679 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NKX2-2 Antibody (aa89-138) - LS-C201248 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of Human Jurkat. NKX2-2 antibody dilution 1.0 ug/ml.

Anti-NKX2-2 Antibody (aa91-120) - LS-C164896 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

NKX2-2 Antibody western blot of 293 cell line lysates (35 ug/lane). The NKX2-2 antibody detected the NKX2-2 protein (arrow).

Anti-NKX2-2 Antibody (clone 3E4) - LS-C169081 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3E4

Western blot using NKX2.2 monoclonal antibody against human NKX2.2 recombinant protein.(Expected MW is 22 kDa)

Anti-NKX2-2 Antibody (Internal) - LS-C153754 from LifeSpan Bioscience

Prices	$345.00, $1,035.00
Sizes	100 µg, 500 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of NKX2-2 in human kidney tissue with NKX2-2 antibody at 2.5 ug/ml.

Anti-NKX2-2 antibody produced in rabbit - AV37110 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Cell Type: SP2/0 (<B>Cat. No. AV37110</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 0.125 μg/mL in cell type SP2/0

NKX2-2 antibody - N-terminal region (ARP37110_P050) - ARP37110_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

NKX2-2 Antibody - 28-618 from ProSci

Prices	$315.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Antibody used in WB on Mouse SP2/0 at 0.125 ug/ml.

NKX2-2 Antibody - GWB-25DCC1 from Genway Biotech

Prices	$336.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Rabbit anti-Mouse Nkx2.2 polyclonal antibody - DPABH-28167 from Creative Diagnostics

Host	Rabbit
Clonality	Polyclonal

Anti-NKX2-2 Antibody (clone NX2/294) - LS-C357991 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	NX2/294

NKX2.2 antibody NX2/294 immunohistochemistry pancreas

Anti-Nkx2.2 Antibody, clone 1C11 - MABD99 from Sigma-Aldrich

Prices	$309.00
Sizes	mabd99
Clonality	Monoclonal

Western Blotting Analysis: <br />Representative lot data. <br />Mouse E13-14 brain tissue lysate was probed with Anti-Nkx2.2, clone 1C11 (1 µg/mL). <br />Proteins were visualized using a Goat Anti-Mouse IgG secondary antibody conjugated to HRP and a chemiluminescence detection system. <br />Arrow indicates Nkx2.2 (~37 kDa). <br />Note: Uncharacterized bands may appear at ~25 kDa and ~300 kDa in some lysates.

Nkx2-2 Antibody,FITC conjugated - CSB-PA015842LC01MO from Cusabio

Host	Rabbit
Clonality	Polyclonal

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