Nkx2-2

Gene Symbol Nkx2-2
Entrez Gene 18088
Alt Symbol Nkx-2.2, Nkx2.2, tinman
Species Mouse
Gene Type protein-coding
Description NK2 homeobox 2
Other Description Drosophila NK2 transcription factor related, locus 2|NK2 transcription factor related, locus 2|glycoprotein GP330, renal|homeobox protein NK-2 homolog B|homeobox protein Nkx-2.2|homeobox protein Nkx2-2
Swissprots P42586
Accessions AAF44652 P42586 AK043561 BAC31582 AK141002 BAE24543 AK162904 BAE37107 BB183898 BC138159 AAI38160 BC138160 AAI38161 U31566 AAA79303 XM_006498898 XP_006498961 XM_006498899 XP_006498962 XM_006498900 XP_006498963 XM_011239349 XP_011237651 NM_001077632 NP_001071100 NM_010919 NP_035049
Function Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. {ECO:0000269|PubMed:19759004}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:14573534}.
Tissue Specificity Expressed in restricted areas of the developing CNS: the hindbrain and forebrain, and pancreas.
Top Pathways Maturity onset diabetes of the young

Nkx-2.2 CRISPR/Cas9 KO Plasmid (m) - sc-421901 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Nkx-2.2 HDR Plasmid (m) - sc-421901-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Nkx-2.2 Double Nickase Plasmid (m) - sc-421901-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Nkx-2.2 Double Nickase Plasmid (m2) - sc-421901-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Nkx-2.2 CRISPR Activation Plasmid (m) - sc-421901-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Nkx-2.2 CRISPR Activation Plasmid (m2) - sc-421901-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Nkx-2.2 Lentiviral Activation Particles (m) - sc-421901-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Nkx-2.2 Lentiviral Activation Particles (m2) - sc-421901-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Nkx-2.2 siRNA (m) - sc-38724 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Nkx-2.2 shRNA Plasmid (m) - sc-38724-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Nkx-2.2 shRNA (m) Lentiviral Particles - sc-38724-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN36484 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36484 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NKX2-2 siRNA (Mouse) - CRM2779 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse Nkx2-2(NM_001077632.1) - SHR011886 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Nkx2-2(NM_010919.2) - SHR011940 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse NKX2-2 siRNA - orb282255 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

NKX2-2 shRNA Plasmid (Mouse) - CHM2779 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

NKX2-2 miRNA 3'UTR clone - MiUTR1M-07673 from Creative biogene

Species Reactivities Mouse

NKX2-2 miRNA 3'UTR clone - MiUTR1M-07674 from Creative biogene

Species Reactivities Mouse
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