| Gene Symbol |
Nkx2-2
|
| Entrez Gene |
18088
|
| Alt Symbol |
Nkx-2.2, Nkx2.2, tinman
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
NK2 homeobox 2
|
| Other Description |
Drosophila NK2 transcription factor related, locus 2|NK2 transcription factor related, locus 2|glycoprotein GP330, renal|homeobox protein NK-2 homolog B|homeobox protein Nkx-2.2|homeobox protein Nkx2-2
|
| Swissprots |
P42586
|
| Accessions |
AAF44652 P42586 AK043561 BAC31582 AK141002 BAE24543 AK162904 BAE37107 BB183898 BC138159 AAI38160 BC138160 AAI38161 U31566 AAA79303 XM_006498898 XP_006498961 XM_006498899 XP_006498962 XM_006498900 XP_006498963 XM_011239349 XP_011237651 NM_001077632 NP_001071100 NM_010919 NP_035049
|
| Function |
Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. {ECO:0000269|PubMed:19759004}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:14573534}.
|
| Tissue Specificity |
Expressed in restricted areas of the developing CNS: the hindbrain and forebrain, and pancreas.
|
| Top Pathways |
Maturity onset diabetes of the young
|