| Gene Symbol |
GCC2
|
| Entrez Gene |
9648
|
| Alt Symbol |
GCC185, RANBP2L4, REN53
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GRIP and coiled-coil domain containing 2
|
| Other Description |
185 kDa Golgi coiled-coil protein|CLL-associated antigen KW-11|CTCL tumor antigen se1-1|GCC protein, 185-kD|GRIP and coiled-coil domain-containing protein 2|Golgi coiled-coil protein GCC185|Ran-binding protein 2-like 4|renal carcinoma antigen NY-REN-53
|
| Swissprots |
Q8TDH3 Q8IWJ2 A6H8X8 O15045 Q9H2G8 Q4ZG46
|
| Accessions |
AAX88838 EAW53882 EAW53883 EAW53884 Q8IWJ2 AA171957 AB002334 BAA20794 AF273042 AAG34902 AF432211 AAL99918 AI084646 AK090813 BAG52233 AK308707 BC020645 AAH20645 BC037774 AAH37774 BC146789 AAI46790 BM694019 DA865539 XM_006712870 XP_006712933 XM_006712871 XP_006712934 XM_006712872 XP_006712935 XM_011512213 XP_011510515 XR_923067 XR_923068 NM_181453 NP_852118 NR_028063
|
| Function |
Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}.
|
| Subcellular Location |
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:11149944}.
|