Gene Symbol | GCC2 |
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Entrez Gene | 9648 |
Alt Symbol | GCC185, RANBP2L4, REN53 |
Species | Human |
Gene Type | protein-coding |
Description | GRIP and coiled-coil domain containing 2 |
Other Description | 185 kDa Golgi coiled-coil protein|CLL-associated antigen KW-11|CTCL tumor antigen se1-1|GCC protein, 185-kD|GRIP and coiled-coil domain-containing protein 2|Golgi coiled-coil protein GCC185|Ran-binding protein 2-like 4|renal carcinoma antigen NY-REN-53 |
Swissprots | Q8TDH3 Q8IWJ2 A6H8X8 O15045 Q9H2G8 Q4ZG46 |
Accessions | AAX88838 EAW53882 EAW53883 EAW53884 Q8IWJ2 AA171957 AB002334 BAA20794 AF273042 AAG34902 AF432211 AAL99918 AI084646 AK090813 BAG52233 AK308707 BC020645 AAH20645 BC037774 AAH37774 BC146789 AAI46790 BM694019 DA865539 XM_006712870 XP_006712933 XM_006712871 XP_006712934 XM_006712872 XP_006712935 XM_011512213 XP_011510515 XR_923067 XR_923068 NM_181453 NP_852118 NR_028063 |
Function | Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}. |
Subcellular Location | Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:11149944}. |
GCC2 CRISPR/Cas9 KO Plasmid (h) - sc-411304 from Santa Cruz Biotechnology
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GCC2 HDR Plasmid (h) - sc-411304-HDR from Santa Cruz Biotechnology
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GCC2 Double Nickase Plasmid (h) - sc-411304-NIC from Santa Cruz Biotechnology
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GCC2 Double Nickase Plasmid (h2) - sc-411304-NIC-2 from Santa Cruz Biotechnology
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GCC2 CRISPR Activation Plasmid (h) - sc-411304-ACT from Santa Cruz Biotechnology
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GCC2 CRISPR Activation Plasmid (h2) - sc-411304-ACT-2 from Santa Cruz Biotechnology
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GCC2 Lentiviral Activation Particles (h) - sc-411304-LAC from Santa Cruz Biotechnology
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GCC2 Lentiviral Activation Particles (h2) - sc-411304-LAC-2 from Santa Cruz Biotechnology
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GCC2 siRNA (h) - sc-94505 from Santa Cruz Biotechnology
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GCC2 shRNA Plasmid (h) - sc-94505-SH from Santa Cruz Biotechnology
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GCC2 shRNA (h) Lentiviral Particles - sc-94505-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN9181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9181 from Sigma-Aldrich
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GCC2 siRNA (Human) - CRH6425 from Cohesion Biosciences
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GCC2 - MBS8212460 from MyBioSource
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shRNA set against Human Gcc2 (NM_181453.3) - SHH299938 from Creative biogene
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Human GCC2 siRNA - orb266927 from Biorbyt
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GCC2 shRNA Plasmid (Human) - CHH6425 from Cohesion Biosciences
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GCC2 miRNA 3'UTR clone - MiUTR3H-12562 from Creative biogene
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