| Gene Symbol | LFNG |
|---|---|
| Entrez Gene | 3955 |
| Alt Symbol | SCDO3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| Other Description | beta-1,3-N-acetylglucosaminyltransferase lunatic fringe |
| Swissprots | Q96C39 O00589 Q9UJW5 B5MCR5 B3KTY6 Q8NES3 |
| Accessions | AAM93542 EAW87250 EAW87251 EAW87252 EAW87253 EAW87254 Q8NES3 AF193612 AAF07187 AK096284 BAG53248 BC014851 AAH14851 BM854210 U94354 AAC51360 NM_001040167 NP_001035257 NM_001040168 NP_001035258 NM_001166355 NP_001159827 NM_002304 NP_002295 |
| Function | Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning (By similarity). {ECO:0000250}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Top Pathways | Other types of O-glycan biosynthesis, Notch signaling pathway |