LFNG
| Gene Symbol | LFNG |
|---|---|
| Entrez Gene | 3955 |
| Alt Symbol | SCDO3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| Other Description | beta-1,3-N-acetylglucosaminyltransferase lunatic fringe |
| Swissprots | Q96C39 O00589 Q9UJW5 B5MCR5 B3KTY6 Q8NES3 |
| Accessions | AAM93542 EAW87250 EAW87251 EAW87252 EAW87253 EAW87254 Q8NES3 AF193612 AAF07187 AK096284 BAG53248 BC014851 AAH14851 BM854210 U94354 AAC51360 NM_001040167 NP_001035257 NM_001040168 NP_001035258 NM_001166355 NP_001159827 NM_002304 NP_002295 |
| Function | Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning (By similarity). {ECO:0000250}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Top Pathways | Other types of O-glycan biosynthesis, Notch signaling pathway |
Lunatic Fringe CRISPR/Cas9 KO Plasmid (h) - sc-409560 from Santa Cruz Biotechnology
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Lunatic Fringe HDR Plasmid (h) - sc-409560-HDR from Santa Cruz Biotechnology
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Lunatic Fringe Double Nickase Plasmid (h) - sc-409560-NIC from Santa Cruz Biotechnology
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Lunatic Fringe Double Nickase Plasmid (h2) - sc-409560-NIC-2 from Santa Cruz Biotechnology
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Lunatic Fringe CRISPR Activation Plasmid (h) - sc-409560-ACT from Santa Cruz Biotechnology
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Lunatic Fringe CRISPR Activation Plasmid (h2) - sc-409560-ACT-2 from Santa Cruz Biotechnology
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Lunatic Fringe Lentiviral Activation Particles (h) - sc-409560-LAC from Santa Cruz Biotechnology
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Lunatic Fringe Lentiviral Activation Particles (h2) - sc-409560-LAC-2 from Santa Cruz Biotechnology
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Lunatic Fringe siRNA (h) - sc-39490 from Santa Cruz Biotechnology
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Lunatic Fringe shRNA Plasmid (h) - sc-39490-SH from Santa Cruz Biotechnology
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Lunatic Fringe shRNA (h) Lentiviral Particles - sc-39490-V from Santa Cruz Biotechnology
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Lunatic Fringe RNAi - H00003955-R01 from Novus Biologicals
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Lunatic Fringe RNAi - H00003955-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN11659 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11659 from Sigma-Aldrich
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LFNG siRNA (Human) - CRH2678 from Cohesion Biosciences
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shRNA set against Human LFNG (NM_001040167.1) - SHH329739 from Creative biogene
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shRNA set against Human LFNG(NM_001040168.1) - SHH146983 from Creative biogene
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shRNA set against Human LFNG(NM_001040167.1) - SHH146997 from Creative biogene
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shRNA set against Human LFNG(NM_001040168.1) - SHH147031 from Creative biogene
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Human LFNG siRNA - orb263180 from Biorbyt
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LFNG shRNA Plasmid (Human) - CHH2678 from Cohesion Biosciences
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LFNG miRNA 3'UTR clone - MiUTR1H-05638 from Creative biogene
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LFNG miRNA 3'UTR clone - MiUTR1H-05639 from Creative biogene
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LFNG miRNA 3'UTR clone - MiUTR4H-TG05032 from Creative biogene
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