| Gene Symbol |
LFNG
|
| Entrez Gene |
3955
|
| Alt Symbol |
SCDO3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
|
| Other Description |
beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
|
| Swissprots |
Q96C39 O00589 Q9UJW5 B5MCR5 B3KTY6 Q8NES3
|
| Accessions |
AAM93542 EAW87250 EAW87251 EAW87252 EAW87253 EAW87254 Q8NES3 AF193612 AAF07187 AK096284 BAG53248 BC014851 AAH14851 BM854210 U94354 AAC51360 NM_001040167 NP_001035257 NM_001040168 NP_001035258 NM_001166355 NP_001159827 NM_002304 NP_002295
|
| Function |
Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Top Pathways |
Other types of O-glycan biosynthesis, Notch signaling pathway
|
![Western Blot: Lunatic Fringe Overexpression Lysate (Adult Normal) [NBP2-10630] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Lunatic Fringe.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6878_Lunatic%2520Fringe%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10630-img0001.jpg)