| Gene Symbol |
SPAG1
|
| Entrez Gene |
6674
|
| Alt Symbol |
CILD28, CT140, HSD-3.8, SP75, TPIS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sperm associated antigen 1
|
| Other Description |
TPR-containing protein involved in spermatogenesis|infertility-related sperm protein Spag-1|sperm-associated antigen 1|tetratricopeptide repeat-containing protein
|
| Swissprots |
A6NP70 Q07617 B3KQ58 Q7Z5G1 G3XAM3
|
| Accessions |
EAW91800 EAW91801 EAW91802 EAW91803 EAW91804 EAW91805 EAW91806 Q07617 AF311312 AAG23967 AI624411 AK057482 BAG51920 BC055091 AAH55091 BM557203 BM981630 BX480304 DB028984 XM_011517240 XP_011515542 XM_011517241 XP_011515543 XM_011517242 XP_011515544 XM_011517243 XP_011515545 XM_011517244 XP_011515546 XM_011517245 XP_011515547 NM_003114 NP_003105 NM_172218 NP_757367
|
| Function |
May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:16983343}. Note=Colocalizes with tubulin.
|
| Tissue Specificity |
Present in most tissues, including lung, with the strongest expression in brain, colon, kidney, and testis. In sperm and testis, detected in particular in pachytene primary spermatocytes. Up-regulated in pancreatic tumor tissues and not in normal pancreatic tissue. {ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558, ECO:0000269|PubMed:16983343, ECO:0000269|PubMed:24055112}.
|
![Western Blot: SPAG1 Overexpression Lysate (Adult Normal) [NBP2-08036] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SPAG1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14487_SPAG1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08036-img0001.jpg)