Gene Symbol | SPAG1 |
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Entrez Gene | 6674 |
Alt Symbol | CILD28, CT140, HSD-3.8, SP75, TPIS |
Species | Human |
Gene Type | protein-coding |
Description | sperm associated antigen 1 |
Other Description | TPR-containing protein involved in spermatogenesis|infertility-related sperm protein Spag-1|sperm-associated antigen 1|tetratricopeptide repeat-containing protein |
Swissprots | A6NP70 Q07617 B3KQ58 Q7Z5G1 G3XAM3 |
Accessions | EAW91800 EAW91801 EAW91802 EAW91803 EAW91804 EAW91805 EAW91806 Q07617 AF311312 AAG23967 AI624411 AK057482 BAG51920 BC055091 AAH55091 BM557203 BM981630 BX480304 DB028984 XM_011517240 XP_011515542 XM_011517241 XP_011515543 XM_011517242 XP_011515544 XM_011517243 XP_011515545 XM_011517244 XP_011515546 XM_011517245 XP_011515547 NM_003114 NP_003105 NM_172218 NP_757367 |
Function | May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:16983343}. Note=Colocalizes with tubulin. |
Tissue Specificity | Present in most tissues, including lung, with the strongest expression in brain, colon, kidney, and testis. In sperm and testis, detected in particular in pachytene primary spermatocytes. Up-regulated in pancreatic tumor tissues and not in normal pancreatic tissue. {ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558, ECO:0000269|PubMed:16983343, ECO:0000269|PubMed:24055112}. |
SPAG1 CRISPR/Cas9 KO Plasmid (h) - sc-409688 from Santa Cruz Biotechnology
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SPAG1 HDR Plasmid (h) - sc-409688-HDR from Santa Cruz Biotechnology
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SPAG1 Double Nickase Plasmid (h) - sc-409688-NIC from Santa Cruz Biotechnology
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SPAG1 Double Nickase Plasmid (h2) - sc-409688-NIC-2 from Santa Cruz Biotechnology
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SPAG1 CRISPR Activation Plasmid (h) - sc-409688-ACT from Santa Cruz Biotechnology
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SPAG1 CRISPR Activation Plasmid (h2) - sc-409688-ACT-2 from Santa Cruz Biotechnology
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SPAG1 Lentiviral Activation Particles (h) - sc-409688-LAC from Santa Cruz Biotechnology
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SPAG1 Lentiviral Activation Particles (h2) - sc-409688-LAC-2 from Santa Cruz Biotechnology
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SPAG1 siRNA (h) - sc-77567 from Santa Cruz Biotechnology
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SPAG1 shRNA Plasmid (h) - sc-77567-SH from Santa Cruz Biotechnology
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SPAG1 shRNA (h) Lentiviral Particles - sc-77567-V from Santa Cruz Biotechnology
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SPAG1 RNAi - H00006674-R01 from Novus Biologicals
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SPAG1 RNAi - H00006674-R02 from Novus Biologicals
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MISSION® esiRNA - EHU122801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20382 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20382 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06861 from Sigma-Aldrich
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SPAG1 siRNA (Human) - CRH4551 from Cohesion Biosciences
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SPAG1 - MBS8202669 from MyBioSource
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shRNA set against Human Spag1 (NM_003114.4) - SHH415768 from Creative biogene
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Human SPAG1 siRNA - orb265053 from Biorbyt
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SPAG1 shRNA Plasmid (Human) - CHH4551 from Cohesion Biosciences
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SPAG1 miRNA 3'UTR clone - MiUTR3H-05927 from Creative biogene
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SPAG1 miRNA 3'UTR clone - MiUTR3H-05928 from Creative biogene
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